A New lncRNA, APTR, Associates with and Represses the CDKN1A/p21 Promoter by Recruiting Polycomb Proteins

Masamitsu Negishi; Somsakul P. Wongpalee; Sukumar Sarkar; Jonghoon Park; Kyung Yong Lee; Yoshiyuki Shibata; Brian J. Reon; Roger Abounader; Yutaka Suzuki; Sumio Sugano; Anindya Dutta

doi:10.1371/journal.pone.0095216

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Research Article

A New lncRNA, APTR, Associates with and Represses the CDKN1A/p21 Promoter by Recruiting Polycomb Proteins

Masamitsu Negishi,

Affiliation Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯
Somsakul P. Wongpalee,

Affiliation Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯
Sukumar Sarkar,

Affiliation Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯
Jonghoon Park,

Affiliation Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯
Kyung Yong Lee,

Affiliation Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯
Yoshiyuki Shibata,

Affiliation Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯
Brian J. Reon,

Affiliation Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯
Roger Abounader,

Affiliation Department of Microbiology, Neurology, University of Virginia, Charlottesville, Virginia, United States of America
⨯
Yutaka Suzuki,

Affiliation The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⨯
Sumio Sugano,

Affiliation The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⨯
Anindya Dutta

* E-mail: ad8q@virginia.edu

Affiliation Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯

A New lncRNA, APTR, Associates with and Represses the CDKN1A/p21 Promoter by Recruiting Polycomb Proteins

Masamitsu Negishi,
Somsakul P. Wongpalee,
Sukumar Sarkar,
Jonghoon Park,
Kyung Yong Lee,
Yoshiyuki Shibata,
Brian J. Reon,
Roger Abounader,
Yutaka Suzuki,
Sumio Sugano

Published: April 18, 2014
https://doi.org/10.1371/journal.pone.0095216

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