Targeted NGF siRNA Delivery Attenuates Sympathetic Nerve Sprouting and Deteriorates Cardiac Dysfunction in Rats with Myocardial Infarction

Hesheng Hu; Yongli Xuan; Ye Wang; Mei Xue; Fei Suo; Xiaolu Li; Wenjuan Cheng; Xinran Li; Jie Yin; Ju Liu; Suhua Yan

doi:10.1371/journal.pone.0095106

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Open Access

Peer-reviewed

Research Article

Targeted NGF siRNA Delivery Attenuates Sympathetic Nerve Sprouting and Deteriorates Cardiac Dysfunction in Rats with Myocardial Infarction

Hesheng Hu ,

Contributed equally to this work with: Hesheng Hu, Yongli Xuan

Affiliations School of Medicine, Shandong University, Jinan, China, Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China
⨯
Yongli Xuan ,

Contributed equally to this work with: Hesheng Hu, Yongli Xuan

Affiliation School of Medicine, Shandong University, Jinan, China
⨯
Ye Wang,

Affiliation Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China
⨯
Mei Xue,

Affiliation Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China
⨯
Fei Suo,

Affiliations School of Medicine, Shandong University, Jinan, China, Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China
⨯
Xiaolu Li,

Affiliation Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China
⨯
Wenjuan Cheng,

Affiliations School of Medicine, Shandong University, Jinan, China, Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China
⨯
Xinran Li,

Affiliation School of Medicine, Shandong University, Jinan, China
⨯
Jie Yin,

Affiliation School of Medicine, Shandong University, Jinan, China
⨯
Ju Liu,

Affiliation Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China
⨯
Suhua Yan

* E-mail: yansuhua5537@163.com

Affiliation Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China
⨯

Targeted NGF siRNA Delivery Attenuates Sympathetic Nerve Sprouting and Deteriorates Cardiac Dysfunction in Rats with Myocardial Infarction

Hesheng Hu,
Yongli Xuan,
Ye Wang,
Mei Xue,
Fei Suo,
Xiaolu Li,
Wenjuan Cheng,
Xinran Li,
Jie Yin,
Ju Liu

Published: April 22, 2014
https://doi.org/10.1371/journal.pone.0095106

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