First Evaluation of Drug-Resistant Mycobacterium tuberculosis Clinical Isolates from Congo Revealed Misdetection of Fluoroquinolone Resistance by Line Probe Assay Due to a Double Substitution T80A-A90G in GyrA

Alexandra Aubry; Wladimir Sougakoff; Pamela Bodzongo; Guy Delcroix; Sylvie Armand; Gérald Millot; Vincent Jarlier; René Courcol; Nadine Lemaître

doi:10.1371/journal.pone.0095083

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Peer-reviewed

Research Article

First Evaluation of Drug-Resistant Mycobacterium tuberculosis Clinical Isolates from Congo Revealed Misdetection of Fluoroquinolone Resistance by Line Probe Assay Due to a Double Substitution T80A-A90G in GyrA

Alexandra Aubry,

Affiliations UPMC Université, Paris, France, INSERM U1135, Paris, France, Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, Paris, France
⨯
Wladimir Sougakoff,

Affiliations UPMC Université, Paris, France, INSERM U1135, Paris, France, Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, Paris, France
⨯
Pamela Bodzongo,

Affiliation Faculté des Sciences de la Santé, Brazzaville, Congo
⨯
Guy Delcroix,

Affiliation Laboratoire de Bactériologie-Hygiène du CHRU, Lille, France
⨯
Sylvie Armand,

Affiliation Laboratoire de Bactériologie-Hygiène du CHRU, Lille, France
⨯
Gérald Millot,

Affiliation Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, Paris, France
⨯
Vincent Jarlier,

Affiliations UPMC Université, Paris, France, INSERM U1135, Paris, France, Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, Paris, France
⨯
René Courcol,

Affiliations Laboratoire de Bactériologie-Hygiène du CHRU, Lille, France, Université Lille Nord de France, Lille, France, UDSL, F-59000 Lille, France, INSERM U1019-UMR8204, Lille, France
⨯
Nadine Lemaître

* E-mail: nadine.lemaitre@chru-lille.fr

Affiliations Laboratoire de Bactériologie-Hygiène du CHRU, Lille, France, Université Lille Nord de France, Lille, France, UDSL, F-59000 Lille, France, INSERM U1019-UMR8204, Lille, France
⨯

First Evaluation of Drug-Resistant Mycobacterium tuberculosis Clinical Isolates from Congo Revealed Misdetection of Fluoroquinolone Resistance by Line Probe Assay Due to a Double Substitution T80A-A90G in GyrA

Alexandra Aubry,
Wladimir Sougakoff,
Pamela Bodzongo,
Guy Delcroix,
Sylvie Armand,
Gérald Millot,
Vincent Jarlier,
René Courcol,
Nadine Lemaître

Published: April 17, 2014
https://doi.org/10.1371/journal.pone.0095083

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Tuberculosis
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Mutation detection
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Antibiotic resistance
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Mycobacterium tuberculosis
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DNA sequencing
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Probe hybridization
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Substitution mutation
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