Numerical and Structural Genomic Aberrations Are Reliably Detectable in Tissue Microarrays of Formalin-Fixed Paraffin-Embedded Tumor Samples by Fluorescence In-Situ Hybridization

Heike Horn; Julia Bausinger; Annette M. Staiger; Maximilian Sohn; Christopher Schmelter; Kim Gruber; Claudia Kalla; M. Michaela Ott; Andreas Rosenwald; German Ott

doi:10.1371/journal.pone.0095047

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Peer-reviewed

Research Article

Numerical and Structural Genomic Aberrations Are Reliably Detectable in Tissue Microarrays of Formalin-Fixed Paraffin-Embedded Tumor Samples by Fluorescence In-Situ Hybridization

Heike Horn,

Affiliation Department of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
⨯
Julia Bausinger,

Affiliation Department of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
⨯
Annette M. Staiger,

Affiliation Department of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
⨯
Maximilian Sohn,

Affiliation Department of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
⨯
Christopher Schmelter,

Affiliation Institute of Pathology, University of Würzburg, Würzburg, Germany
⨯
Kim Gruber,

Affiliation Department of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
⨯
Claudia Kalla,

Affiliation Department of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
⨯
M. Michaela Ott,

Affiliation Institute of Pathology, Caritas-Hospital, Bad Mergentheim, Germany
⨯
Andreas Rosenwald,

Affiliation Institute of Pathology, University of Würzburg, Würzburg, Germany
⨯
German Ott

* E-mail: german.ott@rbk.de

Affiliation Department of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
⨯

Numerical and Structural Genomic Aberrations Are Reliably Detectable in Tissue Microarrays of Formalin-Fixed Paraffin-Embedded Tumor Samples by Fluorescence In-Situ Hybridization

Heike Horn,
Julia Bausinger,
Annette M. Staiger,
Maximilian Sohn,
Christopher Schmelter,
Kim Gruber,
Claudia Kalla,
M. Michaela Ott,
Andreas Rosenwald,
German Ott

Published: April 14, 2014
https://doi.org/10.1371/journal.pone.0095047

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Chromosomal translocations
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Genetic loci
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Chromosomal deletions
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Fluorescent in situ hybridization
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