A Proteolytic Cascade Controls Lysosome Rupture and Necrotic Cell Death Mediated by Lysosome-Destabilizing Adjuvants

Jürgen Brojatsch; Heriberto Lima; Alak K. Kar; Lee S. Jacobson; Stefan M. Muehlbauer; Kartik Chandran; Felipe Diaz-Griffero

doi:10.1371/journal.pone.0095032

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Peer-reviewed

Research Article

A Proteolytic Cascade Controls Lysosome Rupture and Necrotic Cell Death Mediated by Lysosome-Destabilizing Adjuvants

Jürgen Brojatsch ,

Contributed equally to this work with: Jürgen Brojatsch, Heriberto Lima, Alak K. Kar, Lee S. Jacobson

* E-mail: jurgen.brojatsch@einstein.yu.edu

Affiliation Albert Einstein College of Medicine, Department of Microbiology and Immunology, Bronx, New York, United States of America
⨯
Heriberto Lima ,

Contributed equally to this work with: Jürgen Brojatsch, Heriberto Lima, Alak K. Kar, Lee S. Jacobson

Affiliation Albert Einstein College of Medicine, Department of Microbiology and Immunology, Bronx, New York, United States of America
⨯
Alak K. Kar ,

Contributed equally to this work with: Jürgen Brojatsch, Heriberto Lima, Alak K. Kar, Lee S. Jacobson

Affiliation Albert Einstein College of Medicine, Department of Microbiology and Immunology, Bronx, New York, United States of America
⨯
Lee S. Jacobson ,

Contributed equally to this work with: Jürgen Brojatsch, Heriberto Lima, Alak K. Kar, Lee S. Jacobson

Current address: Beth Israel Deaconess Medical Center, Emergency Medicine, Boston, Massachusetts, United States of America.

Affiliation Albert Einstein College of Medicine, Department of Microbiology and Immunology, Bronx, New York, United States of America
⨯
Stefan M. Muehlbauer,

Current address: Beth Israel Deaconess Medical Center, Emergency Medicine, Boston, Massachusetts, United States of America.

Affiliation Albert Einstein College of Medicine, Department of Microbiology and Immunology, Bronx, New York, United States of America
⨯
Kartik Chandran,

Affiliation Albert Einstein College of Medicine, Department of Microbiology and Immunology, Bronx, New York, United States of America
⨯
Felipe Diaz-Griffero

Affiliation Albert Einstein College of Medicine, Department of Microbiology and Immunology, Bronx, New York, United States of America
⨯

A Proteolytic Cascade Controls Lysosome Rupture and Necrotic Cell Death Mediated by Lysosome-Destabilizing Adjuvants

Jürgen Brojatsch,
Heriberto Lima,
Alak K. Kar,
Lee S. Jacobson,
Stefan M. Muehlbauer,
Kartik Chandran,
Felipe Diaz-Griffero

Published: June 3, 2014
https://doi.org/10.1371/journal.pone.0095032

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Lysosomes
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Proteasome inhibitors
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Cell death
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Necrosis
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Proteolysis
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