The “Brittle Response” to Parkinson’s Disease Medications: Characterization and Response to Deep Brain Stimulation

Daniel Martinez-Ramirez; Juan Giugni; Vinata Vedam-Mai; Aparna Wagle Shukla; Irene A. Malaty; Nikolaus R. McFarland; Ramon L. Rodriguez; Kelly D. Foote; Michael S. Okun

doi:10.1371/journal.pone.0094856

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Open Access

Peer-reviewed

Research Article

The “Brittle Response” to Parkinson’s Disease Medications: Characterization and Response to Deep Brain Stimulation

Daniel Martinez-Ramirez,

Affiliation Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America
⨯
Juan Giugni,

Affiliation Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America
⨯
Vinata Vedam-Mai,

Affiliations Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America, Department of Neurosurgery, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America
⨯
Aparna Wagle Shukla,

Affiliation Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America
⨯
Irene A. Malaty,

Affiliation Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America
⨯
Nikolaus R. McFarland,

Affiliation Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America
⨯
Ramon L. Rodriguez,

Affiliation Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America
⨯
Kelly D. Foote,

Affiliation Department of Neurosurgery, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America
⨯
Michael S. Okun

* E-mail: okun@neurology.ufl.edu

Affiliations Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America, Department of Neurosurgery, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America
⨯

The “Brittle Response” to Parkinson’s Disease Medications: Characterization and Response to Deep Brain Stimulation

Daniel Martinez-Ramirez,
Juan Giugni,
Vinata Vedam-Mai,
Aparna Wagle Shukla,
Irene A. Malaty,
Nikolaus R. McFarland,
Ramon L. Rodriguez,
Kelly D. Foote,
Michael S. Okun

Published: April 14, 2014
https://doi.org/10.1371/journal.pone.0094856

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