High Resolution Systematic Digital Histological Quantification of Cardiac Fibrosis and Adipose Tissue in Phospholamban p.Arg14del Mutation Associated Cardiomyopathy

Johannes M. I. H. Gho; René van Es; Nikolas Stathonikos; Magdalena Harakalova; Wouter P. te Rijdt; Albert J. H. Suurmeijer; Jeroen F. van der Heijden; Nicolaas de Jonge; Steven A. J. Chamuleau; Roel A. de Weger; Folkert W. Asselbergs; Aryan Vink

doi:10.1371/journal.pone.0094820

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Open Access

Peer-reviewed

Research Article

High Resolution Systematic Digital Histological Quantification of Cardiac Fibrosis and Adipose Tissue in Phospholamban p.Arg14del Mutation Associated Cardiomyopathy

Johannes M. I. H. Gho,

Affiliation Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands
⨯
René van Es,

Affiliation Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands
⨯
Nikolas Stathonikos,

Affiliation Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands
⨯
Magdalena Harakalova,

Affiliations Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands, Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands
⨯
Wouter P. te Rijdt,

Affiliation Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
⨯
Albert J. H. Suurmeijer,

Affiliation Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
⨯
Jeroen F. van der Heijden,

Affiliation Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands
⨯
Nicolaas de Jonge,

Affiliation Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands
⨯
Steven A. J. Chamuleau,

Affiliation Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands
⨯
Roel A. de Weger,

Affiliation Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands
⨯
Folkert W. Asselbergs,

Affiliations Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands, Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, the Netherlands, Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, United Kingdom
⨯
Aryan Vink

* E-mail: a.vink@umcutrecht.nl

Affiliation Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands
⨯

High Resolution Systematic Digital Histological Quantification of Cardiac Fibrosis and Adipose Tissue in Phospholamban p.Arg14del Mutation Associated Cardiomyopathy

Johannes M. I. H. Gho,
René van Es,
Nikolas Stathonikos,
Magdalena Harakalova,
Wouter P. te Rijdt,
Albert J. H. Suurmeijer,
Jeroen F. van der Heijden,
Nicolaas de Jonge,
Steven A. J. Chamuleau,
Roel A. de Weger

Published: April 14, 2014
https://doi.org/10.1371/journal.pone.0094820

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Fibrosis
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Cardiac ventricles
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Adipose tissue
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Heart
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Cardiomyopathies
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Myocardium
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Magnetic resonance imaging
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