Antiplatelet Activity, P2Y1 and P2Y12 Inhibition, and Metabolism in Plasma of Stereoisomers of Diadenosine 5′,5′″-P1,P4-dithio-P2,P3-chloromethylenetetraphosphate

Hung Chang; Ivan B. Yanachkov; Edward J. Dix; Milka Yanachkova; YouFu Li; Marc R. Barnard; George E. Wright; Alan D. Michelson; Andrew L. Frelinger III

doi:10.1371/journal.pone.0094780

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Peer-reviewed

Research Article

Antiplatelet Activity, P2Y₁ and P2Y₁₂ Inhibition, and Metabolism in Plasma of Stereoisomers of Diadenosine 5′,5′″-P¹,P⁴-dithio-P²,P³-chloromethylenetetraphosphate

Hung Chang,

Affiliations Center for Platelet Function Studies, Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Hematology Division, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
⨯
Ivan B. Yanachkov,

Affiliation GLSynthesis Inc., Worcester, Massachusetts, United States of America
⨯
Edward J. Dix,

Affiliation GLSynthesis Inc., Worcester, Massachusetts, United States of America
⨯
Milka Yanachkova,

Affiliation GLSynthesis Inc., Worcester, Massachusetts, United States of America
⨯
YouFu Li,

Affiliation Center for Platelet Function Studies, Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Marc R. Barnard,

Affiliation Center for Platelet Function Studies, Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
George E. Wright,

Affiliation GLSynthesis Inc., Worcester, Massachusetts, United States of America
⨯
Alan D. Michelson,

Affiliations Center for Platelet Function Studies, Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Center for Platelet Research Studies, Division of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Andrew L. Frelinger III

* E-mail: Andrew.Frelinger@childrens.harvard.edu

Affiliations Center for Platelet Function Studies, Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Center for Platelet Research Studies, Division of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Antiplatelet Activity, P2Y₁ and P2Y₁₂ Inhibition, and Metabolism in Plasma of Stereoisomers of Diadenosine 5′,5′″-P¹,P⁴-dithio-P²,P³-chloromethylenetetraphosphate

Hung Chang,
Ivan B. Yanachkov,
Edward J. Dix,
Milka Yanachkova,
YouFu Li,
Marc R. Barnard,
George E. Wright,
Alan D. Michelson,
Andrew L. Frelinger III

Published: April 10, 2014
https://doi.org/10.1371/journal.pone.0094780

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