Activation of MAPK and FoxO by Manganese (Mn) in Rat Neonatal Primary Astrocyte Cultures

Vernat Exil; Li Ping; Yingchun Yu; Sudipta Chakraborty; Samuel W. Caito; K. Sam Wells; Pratap Karki; Eunsook Lee; Michael Aschner

doi:10.1371/journal.pone.0094753

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Open Access

Peer-reviewed

Research Article

Activation of MAPK and FoxO by Manganese (Mn) in Rat Neonatal Primary Astrocyte Cultures

Vernat Exil ,

* E-mail: vernat.exil@vanderbilt.edu

Affiliation Department of Pediatrics, Thomas P. Graham Division of Pediatric Cardiology, Monroe Carrell Jr. Children's Hospital, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Li Ping,

Affiliation Department of Pediatrics, Division of Pediatric Toxicology, Monroe Carrell Jr. Children's Hospital, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Yingchun Yu,

Affiliation Department of Pediatrics, Division of Pediatric Toxicology, Monroe Carrell Jr. Children's Hospital, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Sudipta Chakraborty,

Affiliation Department of Pediatrics, Division of Pediatric Toxicology, Monroe Carrell Jr. Children's Hospital, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Samuel W. Caito,

Affiliation Department of Pediatrics, Division of Pediatric Toxicology, Monroe Carrell Jr. Children's Hospital, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
K. Sam Wells,

Affiliation Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Pratap Karki,

Affiliation Department of Physiology, Meharry Medical College, Nashville, Tennessee, United States of America
⨯
Eunsook Lee,

Affiliation Department of Physiology, Meharry Medical College, Nashville, Tennessee, United States of America
⨯
Michael Aschner

Affiliation Department of Pediatrics, Division of Pediatric Toxicology, Monroe Carrell Jr. Children's Hospital, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯

Activation of MAPK and FoxO by Manganese (Mn) in Rat Neonatal Primary Astrocyte Cultures

Vernat Exil,
Li Ping,
Yingchun Yu,
Sudipta Chakraborty,
Samuel W. Caito,
K. Sam Wells,
Pratap Karki,
Eunsook Lee,
Michael Aschner

Published: May 2, 2014
https://doi.org/10.1371/journal.pone.0094753

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Manganese
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Astrocytes
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Phosphorylation
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Parkinson disease
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MAPK signaling cascades
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Gene regulation
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