Multivalent Presentation of MPL by Porous Silicon Microparticles Favors T Helper 1 Polarization Enhancing the Anti-Tumor Efficacy of Doxorubicin Nanoliposomes

• Ismail M. Meraz ,

  Contributed equally to this work with: Ismail M. Meraz, Claire H. Hearnden

  Affiliation Nanomedicine, Houston Methodist Research Institute, Houston, Texas, United States of America

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• Claire H. Hearnden ,

  Contributed equally to this work with: Ismail M. Meraz, Claire H. Hearnden

  Affiliation Adjuvant Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland

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• Xuewu Liu,

  Affiliation Nanomedicine, Houston Methodist Research Institute, Houston, Texas, United States of America

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• Marie Yang,

  Affiliations Adjuvant Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland, Advanced Materials and BioEngineering Research (AMBER), Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Trinity College, Dublin, Ireland

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• Laura Williams,

  Affiliations Adjuvant Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland, Advanced Materials and BioEngineering Research (AMBER), Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Trinity College, Dublin, Ireland

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• David J. Savage,

  Affiliations Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, United States of America, The University of Texas School of Medicine, Houston, Texas, United States of America

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• Jianhua Gu,

  Affiliation Nanomedicine, Houston Methodist Research Institute, Houston, Texas, United States of America

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• Jessica R. Rhudy,

  Affiliation Nanomedicine, Houston Methodist Research Institute, Houston, Texas, United States of America

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• Kenji Yokoi,

  Affiliation Nanomedicine, Houston Methodist Research Institute, Houston, Texas, United States of America

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• Ed C. Lavelle ,

  ¶These authors also contributed equally to this work.

  Affiliations Adjuvant Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland, Advanced Materials and BioEngineering Research (AMBER), Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Trinity College, Dublin, Ireland

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• Rita E. Serda

  * E-mail: ritaserda@gmail.com

  ¶These authors also contributed equally to this work.

  Affiliations Nanomedicine, Houston Methodist Research Institute, Houston, Texas, United States of America, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, United States of America

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