Antinociceptive Effect of Tetrandrine on LPS-Induced Hyperalgesia via the Inhibition of IKKβ Phosphorylation and the COX-2/PGE2 Pathway in Mice

Open Access

Peer-reviewed

Research Article

Antinociceptive Effect of Tetrandrine on LPS-Induced Hyperalgesia via the Inhibition of IKKβ Phosphorylation and the COX-2/PGE₂ Pathway in Mice

Hengguang Zhao,

Affiliation Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Fuling Luo,

Affiliation Department of Pharmacy, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Hongzhong Li,

Affiliation Molecular oncology and epigenetics laboratory, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Li Zhang,

Affiliation Department of Pathophysiology, Chongqing Medical University, Chongqing, China
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Yongfen Yi ,

* E-mail: yiyongfen1953@aliyun.com (YFY); jywan@cqmu.edu.cn (JYW)

Affiliation Department of Pathology, Molecular Medicine and Tumor Center, Chongqing Medical University, Chongqing, China
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Jingyuan Wan

* E-mail: yiyongfen1953@aliyun.com (YFY); jywan@cqmu.edu.cn (JYW)

Affiliation Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, China
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Hyperalgesia
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Phosphorylation
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Small interfering RNA
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Transcription factors
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Inflammation
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Pain
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Mouse models
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Morphine
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