Tyrosine 402 Phosphorylation of Pyk2 Is Involved in Ionomycin-Induced Neurotransmitter Release

Zhao Zhang; Yun Zhang; Zheng Mou; Shifeng Chu; Xiaoyu Chen; Wenbin He; Xiaofeng Guo; Yuhe Yuan; Masami Takahashi; Naihong Chen

doi:10.1371/journal.pone.0094574

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Open Access

Peer-reviewed

Research Article

Tyrosine 402 Phosphorylation of Pyk2 Is Involved in Ionomycin-Induced Neurotransmitter Release

Zhao Zhang,

Affiliation State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, and neuroscience center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China
⨯
Yun Zhang,

Affiliation State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, and neuroscience center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China
⨯
Zheng Mou,

Affiliation State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, and neuroscience center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China
⨯
Shifeng Chu,

Affiliation State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, and neuroscience center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China
⨯
Xiaoyu Chen,

Affiliation State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, and neuroscience center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China
⨯
Wenbin He,

Affiliations State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, and neuroscience center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China, Basic Medical College, Shanxi University of Traditional Chinese Medicine, Taiyuan, People’s Republic of China
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Xiaofeng Guo,

Affiliation Basic Medical College, Shanxi University of Traditional Chinese Medicine, Taiyuan, People’s Republic of China
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Yuhe Yuan,

Affiliation State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, and neuroscience center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China
⨯
Masami Takahashi ,

* E-mail: chennh@imm.ac.cn (NC); masami@med.kitasato-u.ac.jp (MT)

Affiliation Department of Biochemistry, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
⨯
Naihong Chen

* E-mail: chennh@imm.ac.cn (NC); masami@med.kitasato-u.ac.jp (MT)

Affiliation State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, and neuroscience center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China
⨯

Tyrosine 402 Phosphorylation of Pyk2 Is Involved in Ionomycin-Induced Neurotransmitter Release

Zhao Zhang,
Yun Zhang,
Zheng Mou,
Shifeng Chu,
Xiaoyu Chen,
Wenbin He,
Xiaofeng Guo,
Yuhe Yuan,
Masami Takahashi,
Naihong Chen

Published: April 9, 2014
https://doi.org/10.1371/journal.pone.0094574

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