A Novel Berbamine Derivative Inhibits Cell Viability and Induces Apoptosis in Cancer Stem-Like Cells of Human Glioblastoma, via Up-Regulation of miRNA-4284 and JNK/AP-1 Signaling

Fan Yang; Sangkil Nam; Christine E. Brown; Robin Zhao; Renate Starr; David A. Horne; Linda H. Malkas; Richard Jove; Robert J. Hickey

doi:10.1371/journal.pone.0094443

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Peer-reviewed

Research Article

A Novel Berbamine Derivative Inhibits Cell Viability and Induces Apoptosis in Cancer Stem-Like Cells of Human Glioblastoma, via Up-Regulation of miRNA-4284 and JNK/AP-1 Signaling

Fan Yang,

Affiliation Translational Biomarker Discovery Core, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, California, United States of America
⨯
Sangkil Nam,

Affiliation Molecular Medicine, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, California, United States of America
⨯
Christine E. Brown,

Affiliation Cancer Immunotherapeutics & Tumor Immunology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, California, United States of America
⨯
Robin Zhao,

Affiliation Molecular Medicine, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, California, United States of America
⨯
Renate Starr,

Affiliation Cancer Immunotherapeutics & Tumor Immunology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, California, United States of America
⨯
David A. Horne,

Affiliation Molecular Medicine, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, California, United States of America
⨯
Linda H. Malkas,

Affiliation Molecular and Cellular Biology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, California, United States of America
⨯
Richard Jove,

Affiliation Vaccine & Gene Therapy Institute of Florida, Port St. Lucie, Florida, United States of America
⨯
Robert J. Hickey

* E-mail: rohickey@coh.org

Affiliations Translational Biomarker Discovery Core, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, California, United States of America, Molecular Pharmacology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, California, United States of America
⨯

A Novel Berbamine Derivative Inhibits Cell Viability and Induces Apoptosis in Cancer Stem-Like Cells of Human Glioblastoma, via Up-Regulation of miRNA-4284 and JNK/AP-1 Signaling

Fan Yang,
Sangkil Nam,
Christine E. Brown,
Robin Zhao,
Renate Starr,
David A. Horne,
Linda H. Malkas,
Richard Jove,
Robert J. Hickey

Published: April 14, 2014
https://doi.org/10.1371/journal.pone.0094443

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