Attenuation of Pathogenic Immune Responses during Infection with Human and Simian Immunodeficiency Virus (HIV/SIV) by the Tetracycline Derivative Minocycline

Julia L. Drewes; Gregory L. Szeto; Elizabeth L. Engle; Zhaohao Liao; Gene M. Shearer; M. Christine Zink; David R. Graham

doi:10.1371/journal.pone.0094375

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Peer-reviewed

Research Article

Attenuation of Pathogenic Immune Responses during Infection with Human and Simian Immunodeficiency Virus (HIV/SIV) by the Tetracycline Derivative Minocycline

Julia L. Drewes,

Affiliation Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Gregory L. Szeto,

Current address: Departments of Materials Science and Engineering, Biological Engineering, and the David H. Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology, and the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, Massachusetts, United States of America

Affiliation Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Elizabeth L. Engle,

Affiliation Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Zhaohao Liao,

Affiliation Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Gene M. Shearer,

Affiliation Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
M. Christine Zink ,

* E-mail: dgraham@jhmi.edu (DRG); mczink@jhmi.edu (MCZ)

Affiliation Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
David R. Graham

* E-mail: dgraham@jhmi.edu (DRG); mczink@jhmi.edu (MCZ)

Affiliations Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Johns Hopkins Bayview Proteomics Center, Department of Medicine, Division of Cardiology, Johns Hopkins School of Medicine Bayview Campus, Baltimore, Maryland, United States of America
⨯

Attenuation of Pathogenic Immune Responses during Infection with Human and Simian Immunodeficiency Virus (HIV/SIV) by the Tetracycline Derivative Minocycline

Julia L. Drewes,
Gregory L. Szeto,
Elizabeth L. Engle,
Zhaohao Liao,
Gene M. Shearer,
M. Christine Zink,
David R. Graham

Published: April 14, 2014
https://doi.org/10.1371/journal.pone.0094375

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