The Early Activation of Toll-Like Receptor (TLR)-3 Initiates Kidney Injury after Ischemia and Reperfusion

Patrick Paulus; Katrin Rupprecht; Patrick Baer; Nicholas Obermüller; Daniela Penzkofer; Christin Reissig; Bertram Scheller; Johannes Holfeld; Kai Zacharowski; Stefanie Dimmeler; Joelle Schlammes; Anja Urbschat

doi:10.1371/journal.pone.0094366

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Open Access

Peer-reviewed

Research Article

The Early Activation of Toll-Like Receptor (TLR)-3 Initiates Kidney Injury after Ischemia and Reperfusion

Patrick Paulus ,

* E-mail: patrick.paulus@kgu.de

Affiliation Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Hospital Frankfurt, Frankfurt am Main, Germany
⨯
Katrin Rupprecht,

Affiliation Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Hospital Frankfurt, Frankfurt am Main, Germany
⨯
Patrick Baer,

Affiliation Department of Internal Medicine III, Division of Nephrology, Goethe-University Hospital, Frankfurt am Main, Germany
⨯
Nicholas Obermüller,

Affiliation Department of Internal Medicine III, Division of Nephrology, Goethe-University Hospital, Frankfurt am Main, Germany
⨯
Daniela Penzkofer,

Affiliation Institute of Cardiovascular Regeneration, Goethe-University, Frankfurt am Main, Germany
⨯
Christin Reissig,

Affiliation Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Hospital Frankfurt, Frankfurt am Main, Germany
⨯
Bertram Scheller,

Affiliation Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Hospital Frankfurt, Frankfurt am Main, Germany
⨯
Johannes Holfeld,

Affiliation Department of Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria
⨯
Kai Zacharowski,

Affiliation Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Hospital Frankfurt, Frankfurt am Main, Germany
⨯
Stefanie Dimmeler,

Affiliation Institute of Cardiovascular Regeneration, Goethe-University, Frankfurt am Main, Germany
⨯
Joelle Schlammes,

Affiliation Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Goethe-University Hospital Frankfurt, Frankfurt am Main, Germany
⨯
Anja Urbschat

Affiliation Faculty of Medicine, Philipps-University Marburg, Marburg, Germany
⨯

The Early Activation of Toll-Like Receptor (TLR)-3 Initiates Kidney Injury after Ischemia and Reperfusion

Patrick Paulus,
Katrin Rupprecht,
Patrick Baer,
Nicholas Obermüller,
Daniela Penzkofer,
Christin Reissig,
Bertram Scheller,
Johannes Holfeld,
Kai Zacharowski,
Stefanie Dimmeler

Published: April 15, 2014
https://doi.org/10.1371/journal.pone.0094366

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Kidneys
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Reperfusion
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Toll-like receptors
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Protein expression
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Urinary biomarkers
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Ischemia
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