Evaluation of Patterns of Liver Toxicity in Patients on Antiretroviral and Anti-Tuberculosis Drugs: A Prospective Four Arm Observational Study in Ethiopian Patients

Getnet Yimer; Marcus Gry; Wondwossen Amogne; Eyasu Makonnen; Abiy Habtewold; Zelalem Petros; Getachew Aderaye; Ina Schuppe-Koistinen; Lars Lindquist; Eleni Aklillu

doi:10.1371/journal.pone.0094271

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Open Access

Peer-reviewed

Research Article

Evaluation of Patterns of Liver Toxicity in Patients on Antiretroviral and Anti-Tuberculosis Drugs: A Prospective Four Arm Observational Study in Ethiopian Patients

Getnet Yimer,

Affiliations Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge C1:68, Karolinska Institutet, Stockholm, Sweden, Department of Pharmacology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
⨯
Marcus Gry,

Affiliation Former AstraZeneca R&D, Global Safety Assessment, Molecular Toxicology, Södertälje, Sweden
⨯
Wondwossen Amogne,

Affiliations Department of Internal Medicine, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia, Department of Medicine, Division of Infectious Diseases, Karolinska Institute at Karolinska University Hospital Huddinge I:73, Stockholm, Sweden
⨯
Eyasu Makonnen,

Affiliation Department of Pharmacology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
⨯
Abiy Habtewold,

Affiliations Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge C1:68, Karolinska Institutet, Stockholm, Sweden, Department of Pharmacology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
⨯
Zelalem Petros,

Affiliation Department of Pharmacology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
⨯
Getachew Aderaye,

Affiliation Department of Internal Medicine, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
⨯
Ina Schuppe-Koistinen,

Affiliation AstraZeneca Innovative Medicines Personalised Healthcare & Biomarkers, Science for Life Laboratory, Solna, Sweden
⨯
Lars Lindquist,

Affiliation Department of Medicine, Division of Infectious Diseases, Karolinska Institute at Karolinska University Hospital Huddinge I:73, Stockholm, Sweden
⨯
Eleni Aklillu

* E-mail: Eleni.Aklillu@ki.se

Affiliation Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge C1:68, Karolinska Institutet, Stockholm, Sweden
⨯

Evaluation of Patterns of Liver Toxicity in Patients on Antiretroviral and Anti-Tuberculosis Drugs: A Prospective Four Arm Observational Study in Ethiopian Patients

Getnet Yimer,
Marcus Gry,
Wondwossen Amogne,
Eyasu Makonnen,
Abiy Habtewold,
Zelalem Petros,
Getachew Aderaye,
Ina Schuppe-Koistinen,
Lars Lindquist,
Eleni Aklillu

Published: April 8, 2014
https://doi.org/10.1371/journal.pone.0094271

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Highly-active antiretroviral therapy
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HIV
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