Specificity of Anti-Tau Antibodies when Analyzing Mice Models of Alzheimer's Disease: Problems and Solutions

Franck R. Petry; Jérôme Pelletier; Alexis Bretteville; Françoise Morin; Frédéric Calon; Sébastien S. Hébert; Robert A. Whittington; Emmanuel Planel

doi:10.1371/journal.pone.0094251

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Peer-reviewed

Research Article

Specificity of Anti-Tau Antibodies when Analyzing Mice Models of Alzheimer's Disease: Problems and Solutions

Franck R. Petry,

Affiliations Université Laval, Faculté de Médecine, Départment de Psychiatrie et Neurosciences, Québec, Canada, Centre de Recherche du CHU de Québec, CHUL, Axe Neurosciences, Québec, Canada
⨯
Jérôme Pelletier,

Affiliations Université Laval, Faculté de Médecine, Départment de Psychiatrie et Neurosciences, Québec, Canada, Centre de Recherche du CHU de Québec, CHUL, Axe Neurosciences, Québec, Canada
⨯
Alexis Bretteville,

Affiliations Université Laval, Faculté de Médecine, Départment de Psychiatrie et Neurosciences, Québec, Canada, Centre de Recherche du CHU de Québec, CHUL, Axe Neurosciences, Québec, Canada
⨯
Françoise Morin,

Affiliation Centre de Recherche du CHU de Québec, CHUL, Axe Neurosciences, Québec, Canada
⨯
Frédéric Calon,

Affiliations Université Laval, Faculté de Pharmacie, Québec, Canada, Centre de Recherche du CHU de Québec, CHUL, Axe Neurosciences, Québec, Canada
⨯
Sébastien S. Hébert,

Affiliations Université Laval, Faculté de Médecine, Départment de Psychiatrie et Neurosciences, Québec, Canada, Centre de Recherche du CHU de Québec, CHUL, Axe Neurosciences, Québec, Canada
⨯
Robert A. Whittington,

Affiliation Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America
⨯
Emmanuel Planel

* E-mail: emmanuel@planel.org

Affiliations Université Laval, Faculté de Médecine, Départment de Psychiatrie et Neurosciences, Québec, Canada, Centre de Recherche du CHU de Québec, CHUL, Axe Neurosciences, Québec, Canada
⨯

Specificity of Anti-Tau Antibodies when Analyzing Mice Models of Alzheimer's Disease: Problems and Solutions

Franck R. Petry,
Jérôme Pelletier,
Alexis Bretteville,
Françoise Morin,
Frédéric Calon,
Sébastien S. Hébert,
Robert A. Whittington,
Emmanuel Planel

Published: May 2, 2014
https://doi.org/10.1371/journal.pone.0094251

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08 May 2014
09:35 GMT
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Mouse models
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Monoclonal antibodies
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Phosphorylation
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Antibodies
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Tau protein
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Antibody production
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Alzheimer's disease
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