Impact of Mutations in Highly Conserved Amino Acids of the HIV-1 Gag-p24 and Env-gp120 Proteins on Viral Replication in Different Genetic Backgrounds

Yi Liu; Ushnal Rao; Jan McClure; Philip Konopa; Siriphan Manocheewa; Moon Kim; Lennie Chen; Ryan M. Troyer; Denis M. Tebit; Sarah Holte; Eric J. Arts; James I. Mullins

doi:10.1371/journal.pone.0094240

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Open Access

Peer-reviewed

Research Article

Impact of Mutations in Highly Conserved Amino Acids of the HIV-1 Gag-p24 and Env-gp120 Proteins on Viral Replication in Different Genetic Backgrounds

Yi Liu ,

* E-mail: yiliu197@uw.edu

Affiliation Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America
⨯
Ushnal Rao,

Affiliation Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America
⨯
Jan McClure,

Affiliation Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America
⨯
Philip Konopa,

Affiliation Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America
⨯
Siriphan Manocheewa,

Affiliation Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America
⨯
Moon Kim,

Affiliation Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America
⨯
Lennie Chen,

Affiliation Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America
⨯
Ryan M. Troyer,

Current address: Dept. of Microbiology, Immunology & Pathology, Colorado State University, Fort Collins, Colorado, United States of America

Affiliation Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Denis M. Tebit,

Affiliation Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Sarah Holte,

Affiliation Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Eric J. Arts,

Affiliation Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
James I. Mullins

Affiliations Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America, Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
⨯

Impact of Mutations in Highly Conserved Amino Acids of the HIV-1 Gag-p24 and Env-gp120 Proteins on Viral Replication in Different Genetic Backgrounds

Yi Liu,
Ushnal Rao,
Jan McClure,
Philip Konopa,
Siriphan Manocheewa,
Moon Kim,
Lennie Chen,
Ryan M. Troyer,
Denis M. Tebit,
Sarah Holte

Published: April 8, 2014
https://doi.org/10.1371/journal.pone.0094240

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