A 5000-Fold Increase in the Specificity of a Bacterial Phosphotriesterase for Malathion through Combinatorial Active Site Mutagenesis

• Tatheer Naqvi,

  Affiliations Department of Environmental Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan, Ecosystem Sciences, Commonwealth Scientific and Industrial Research Organisation, Canberra, Australian Capital Territory, Australia

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• Andrew C. Warden,

  Affiliation Ecosystem Sciences, Commonwealth Scientific and Industrial Research Organisation, Canberra, Australian Capital Territory, Australia

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• Nigel French,

  Affiliation Ecosystem Sciences, Commonwealth Scientific and Industrial Research Organisation, Canberra, Australian Capital Territory, Australia

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• Elena Sugrue,

  Affiliation Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia

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• Paul D. Carr,

  Affiliation Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia

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• Colin J. Jackson,

  Affiliation Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia

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• Colin Scott

  * E-mail: colin.scott@csiro.au

  Affiliation Ecosystem Sciences, Commonwealth Scientific and Industrial Research Organisation, Canberra, Australian Capital Territory, Australia

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