Cytoplasmic Retention of a Nucleocytoplasmic Protein TBC1D3 by Microtubule Network Is Required for Enhanced EGFR Signaling

Ze He; Tian Tian; Dan Guo; Huijuan Wu; Yang Chen; Yongchen Zhang; Qing Wan; Huzi Zhao; Congyang Wang; Hongjing Shen; Lei Zhao; Xiaodong Bu; Meiling Wan; Chuanlu Shen

doi:10.1371/journal.pone.0094134

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Open Access

Peer-reviewed

Research Article

Cytoplasmic Retention of a Nucleocytoplasmic Protein TBC1D3 by Microtubule Network Is Required for Enhanced EGFR Signaling

Ze He ,

Contributed equally to this work with: Ze He, Tian Tian

Affiliations Department of Pathology and Pathophysiology, Medical School, Southeast University, Nanjing, Jiangsu, People's Republic of China, Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, People's Republic of China
⨯
Tian Tian ,

Contributed equally to this work with: Ze He, Tian Tian

Affiliation Department of Pathology and Pathophysiology, Medical School, Southeast University, Nanjing, Jiangsu, People's Republic of China
⨯
Dan Guo,

Affiliation Department of Pathology and Pathophysiology, Medical School, Southeast University, Nanjing, Jiangsu, People's Republic of China
⨯
Huijuan Wu,

Affiliation Department of Pathology and Pathophysiology, Medical School, Southeast University, Nanjing, Jiangsu, People's Republic of China
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Yang Chen,

Affiliation Department of Pathology and Pathophysiology, Medical School, Southeast University, Nanjing, Jiangsu, People's Republic of China
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Yongchen Zhang,

Affiliation Department of Pathology and Pathophysiology, Medical School, Southeast University, Nanjing, Jiangsu, People's Republic of China
⨯
Qing Wan,

Affiliation Department of Pathology and Pathophysiology, Medical School, Southeast University, Nanjing, Jiangsu, People's Republic of China
⨯
Huzi Zhao,

Affiliation Department of Pathology and Pathophysiology, Medical School, Southeast University, Nanjing, Jiangsu, People's Republic of China
⨯
Congyang Wang,

Affiliation Department of Pathology and Pathophysiology, Medical School, Southeast University, Nanjing, Jiangsu, People's Republic of China
⨯
Hongjing Shen,

Affiliation Department of Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, United States of America
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Lei Zhao,

Affiliation Department of Pathology and Pathophysiology, Medical School, Southeast University, Nanjing, Jiangsu, People's Republic of China
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Xiaodong Bu,

Affiliation Department of Pathology and Pathophysiology, Medical School, Southeast University, Nanjing, Jiangsu, People's Republic of China
⨯
Meiling Wan,

Affiliation Department of Pathology and Pathophysiology, Medical School, Southeast University, Nanjing, Jiangsu, People's Republic of China
⨯
Chuanlu Shen

* E-mail: shencl37@163.com

Affiliation Department of Pathology and Pathophysiology, Medical School, Southeast University, Nanjing, Jiangsu, People's Republic of China
⨯

Cytoplasmic Retention of a Nucleocytoplasmic Protein TBC1D3 by Microtubule Network Is Required for Enhanced EGFR Signaling

Ze He,
Tian Tian,
Dan Guo,
Huijuan Wu,
Yang Chen,
Yongchen Zhang,
Qing Wan,
Huzi Zhao,
Congyang Wang,
Hongjing Shen

Published: April 8, 2014
https://doi.org/10.1371/journal.pone.0094134

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Microtubules
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Ubiquitination
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Transfection
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EGFR signaling
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Immunoprecipitation
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Tubulins
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Cell membranes
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Co-immunoprecipitation
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