Comprehensive Evaluation of Peripheral Nerve Regeneration in the Acute Healing Phase Using Tissue Clearing and Optical Microscopy in a Rodent Model

Yookyung Jung; Joanna H. Ng; Cameron P. Keating; Prabhu Senthil-Kumar; Jie Zhao; Mark A. Randolph; Jonathan M. Winograd; Conor L. Evans

doi:10.1371/journal.pone.0094054

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Peer-reviewed

Research Article

Comprehensive Evaluation of Peripheral Nerve Regeneration in the Acute Healing Phase Using Tissue Clearing and Optical Microscopy in a Rodent Model

Yookyung Jung ,

Contributed equally to this work with: Yookyung Jung, Joanna H. Ng

Affiliation Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Joanna H. Ng ,

Contributed equally to this work with: Yookyung Jung, Joanna H. Ng

Affiliation Plastic Surgery Research Laboratory, Harvard Medical School, Division of Plastic and Reconstructive Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Cameron P. Keating,

Affiliation Plastic Surgery Research Laboratory, Harvard Medical School, Division of Plastic and Reconstructive Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Prabhu Senthil-Kumar,

Affiliation Plastic Surgery Research Laboratory, Harvard Medical School, Division of Plastic and Reconstructive Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Jie Zhao,

Affiliation Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Mark A. Randolph,

Affiliation Plastic Surgery Research Laboratory, Harvard Medical School, Division of Plastic and Reconstructive Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Jonathan M. Winograd,

Affiliation Plastic Surgery Research Laboratory, Harvard Medical School, Division of Plastic and Reconstructive Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Conor L. Evans

* E-mail: Evans.Conor@mgh.harvard.edu

Affiliation Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯

Comprehensive Evaluation of Peripheral Nerve Regeneration in the Acute Healing Phase Using Tissue Clearing and Optical Microscopy in a Rodent Model

Yookyung Jung,
Joanna H. Ng,
Cameron P. Keating,
Prabhu Senthil-Kumar,
Jie Zhao,
Mark A. Randolph,
Jonathan M. Winograd,
Conor L. Evans

Published: April 8, 2014
https://doi.org/10.1371/journal.pone.0094054

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Axons
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Nerves
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Nerve regeneration
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Immunofluorescence staining
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Tissue repair
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