MNK1-Induced eIF-4E Phosphorylation in Myeloma Cells: A Pathway Mediating IL-6-Induced Expansion and Expression of Genes Involved in Metabolic and Proteotoxic Responses

Yijiang Shi; Patrick Frost; Bao Hoang; Yonghui Yang; Carolyne Bardeleben; Joseph Gera; Alan Lichtenstein

doi:10.1371/journal.pone.0094011

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Research Article

MNK1-Induced eIF-4E Phosphorylation in Myeloma Cells: A Pathway Mediating IL-6-Induced Expansion and Expression of Genes Involved in Metabolic and Proteotoxic Responses

Yijiang Shi,

Affiliations Department of Medicine, Hematology-Oncology, Greater Los Angeles VA Healthcare Center, Los Angeles, California, United States of America, Department of Medicine, UCLA School of Medicine, Los Angeles, California, United States of America, Jonsson Comprehensive Cancer Center, Los Angeles, California, United States of America
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Patrick Frost,

Affiliations Department of Medicine, Hematology-Oncology, Greater Los Angeles VA Healthcare Center, Los Angeles, California, United States of America, Department of Medicine, UCLA School of Medicine, Los Angeles, California, United States of America, Jonsson Comprehensive Cancer Center, Los Angeles, California, United States of America
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Bao Hoang,

Affiliations Department of Medicine, Hematology-Oncology, Greater Los Angeles VA Healthcare Center, Los Angeles, California, United States of America, Department of Medicine, UCLA School of Medicine, Los Angeles, California, United States of America, Jonsson Comprehensive Cancer Center, Los Angeles, California, United States of America
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Yonghui Yang,

Affiliations Department of Medicine, Hematology-Oncology, Greater Los Angeles VA Healthcare Center, Los Angeles, California, United States of America, Department of Medicine, UCLA School of Medicine, Los Angeles, California, United States of America, Jonsson Comprehensive Cancer Center, Los Angeles, California, United States of America
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Carolyne Bardeleben,

Affiliations Department of Medicine, Hematology-Oncology, Greater Los Angeles VA Healthcare Center, Los Angeles, California, United States of America, Department of Medicine, UCLA School of Medicine, Los Angeles, California, United States of America, Jonsson Comprehensive Cancer Center, Los Angeles, California, United States of America
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Joseph Gera,

Affiliations Department of Medicine, Hematology-Oncology, Greater Los Angeles VA Healthcare Center, Los Angeles, California, United States of America, Department of Medicine, UCLA School of Medicine, Los Angeles, California, United States of America, Jonsson Comprehensive Cancer Center, Los Angeles, California, United States of America
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Alan Lichtenstein

* E-mail: alan.lichtenstein@med.va.gov

Affiliations Department of Medicine, Hematology-Oncology, Greater Los Angeles VA Healthcare Center, Los Angeles, California, United States of America, Department of Medicine, UCLA School of Medicine, Los Angeles, California, United States of America, Jonsson Comprehensive Cancer Center, Los Angeles, California, United States of America
⨯

MNK1-Induced eIF-4E Phosphorylation in Myeloma Cells: A Pathway Mediating IL-6-Induced Expansion and Expression of Genes Involved in Metabolic and Proteotoxic Responses

Yijiang Shi,
Patrick Frost,
Bao Hoang,
Yonghui Yang,
Carolyne Bardeleben,
Joseph Gera,
Alan Lichtenstein

Published: April 8, 2014
https://doi.org/10.1371/journal.pone.0094011

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Phosphorylation
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Protein translation
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Multiple myeloma
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Messenger RNA
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Cancers and neoplasms
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Cell growth
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