Vasoreparative Dysfunction of CD34+ Cells in Diabetic Individuals Involves Hypoxic Desensitization and Impaired Autocrine/Paracrine Mechanisms

Yagna P. R. Jarajapu; Sugata Hazra; Mark Segal; Sergio LiCalzi; Chandra Jhadao; Kevin Qian; Sayak K. Mitter; Mohan K. Raizada; Michael E. Boulton; Maria B. Grant

doi:10.1371/journal.pone.0093965

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Open Access

Peer-reviewed

Research Article

Vasoreparative Dysfunction of CD34⁺ Cells in Diabetic Individuals Involves Hypoxic Desensitization and Impaired Autocrine/Paracrine Mechanisms

Yagna P. R. Jarajapu,

Affiliations Department of Pharmaceutical Sciences, College of Pharmacy, Nursing, and Allied Sciences, North Dakota State University, Fargo, North Dakota, United States of America, Departments of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Sugata Hazra,

Affiliation Departments of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Mark Segal,

Affiliation Department of Nephrology, College of Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Sergio LiCalzi,

Affiliation Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Chandra Jhadao,

Affiliation Departments of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Kevin Qian,

Affiliation Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Sayak K. Mitter,

Affiliation Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Mohan K. Raizada,

Affiliation Department of Physiology and Functional Genomics College of Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Michael E. Boulton,

Affiliation Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Maria B. Grant

* E-mail: mabgrant@iupui.edu

Affiliations Departments of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, Florida, United States of America, Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯

Vasoreparative Dysfunction of CD34⁺ Cells in Diabetic Individuals Involves Hypoxic Desensitization and Impaired Autocrine/Paracrine Mechanisms

Yagna P. R. Jarajapu,
Sugata Hazra,
Mark Segal,
Sergio LiCalzi,
Chandra Jhadao,
Kevin Qian,
Sayak K. Mitter,
Mohan K. Raizada,
Michael E. Boulton,
Maria B. Grant

Published: April 8, 2014
https://doi.org/10.1371/journal.pone.0093965

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