Inhibiting Na+/K+ ATPase Can Impair Mitochondrial Energetics and Induce Abnormal Ca2+ Cycling and Automaticity in Guinea Pig Cardiomyocytes

Open Access

Peer-reviewed

Research Article

Inhibiting Na⁺/K⁺ ATPase Can Impair Mitochondrial Energetics and Induce Abnormal Ca²⁺ Cycling and Automaticity in Guinea Pig Cardiomyocytes

Qince Li,

Affiliations Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Comprehensive Cardiovascular Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
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Steven M. Pogwizd,

Affiliations Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Comprehensive Cardiovascular Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
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Sumanth D. Prabhu,

Affiliations Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Comprehensive Cardiovascular Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
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Lufang Zhou

* E-mail: lfzhou@uab.edu

Affiliations Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Comprehensive Cardiovascular Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
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Mitochondria
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Glycosides
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Cardiomyocytes
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Cardiac pacing
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Oxidative stress
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Action potentials
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Cytosol
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Mitochondrial membrane
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