Large-Scale RNA Interference Screening in Mammalian Cells Identifies Novel Regulators of Mutant Huntingtin Aggregation

• Tomoyuki Yamanaka ,

  Contributed equally to this work with: Tomoyuki Yamanaka, Hon Kit Wong

  Affiliations Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan, Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, Saitama, Japan, Laboratory for Molecular Mechanisms of Thalamus Development, RIKEN Brain Science Institute, Saitama, Japan, CREST (Core Research for Evolutionary Science and Technology), JST, Tokyo, Japan

  ⨯
• Hon Kit Wong ,

  Contributed equally to this work with: Tomoyuki Yamanaka, Hon Kit Wong

  Affiliations Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, Saitama, Japan, Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Harvard Institutes of Medicine, Boston, Massachusetts, United States of America

  ⨯
• Asako Tosaki,

  Affiliation Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, Saitama, Japan

  ⨯
• Peter O. Bauer,

  Affiliation Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, Saitama, Japan

  ⨯
• Koji Wada,

  Affiliation Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, Saitama, Japan

  ⨯
• Masaru Kurosawa,

  Affiliations Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan, Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, Saitama, Japan, Laboratory for Molecular Mechanisms of Thalamus Development, RIKEN Brain Science Institute, Saitama, Japan, CREST (Core Research for Evolutionary Science and Technology), JST, Tokyo, Japan

  ⨯
• Tomomi Shimogori,

  Affiliation Laboratory for Molecular Mechanisms of Thalamus Development, RIKEN Brain Science Institute, Saitama, Japan

  ⨯
• Nobutaka Hattori,

  Affiliation Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan

  ⨯
• Nobuyuki Nukina

  * E-mail: nnukina@juntendo.ac.jp

  Affiliations Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan, Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, Saitama, Japan, Laboratory for Molecular Mechanisms of Thalamus Development, RIKEN Brain Science Institute, Saitama, Japan, CREST (Core Research for Evolutionary Science and Technology), JST, Tokyo, Japan

  ⨯