The SLE Transcriptome Exhibits Evidence of Chronic Endotoxin Exposure and Has Widespread Dysregulation of Non-Coding and Coding RNAs

Lihua Shi; Zhe Zhang; Angela M. Yu; Wei Wang; Zhi Wei; Ehtisham Akhter; Kelly Maurer; Patrícia Costa Reis; Li Song; Michelle Petri; Kathleen E. Sullivan

doi:10.1371/journal.pone.0093846

Loading metrics

Open Access

Peer-reviewed

Research Article

The SLE Transcriptome Exhibits Evidence of Chronic Endotoxin Exposure and Has Widespread Dysregulation of Non-Coding and Coding RNAs

Lihua Shi,

Affiliation The Division of Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Zhe Zhang,

Affiliation The Center for Biomedical Informatics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Angela M. Yu,

Affiliation The Center for Biomedical Informatics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Wei Wang,

Affiliation Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey, United States of America
⨯
Zhi Wei,

Affiliation Department of Computer Science, New Jersey Institute of Technology, Newark, New Jersey, United States of America
⨯
Ehtisham Akhter,

Affiliation Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Kelly Maurer,

Affiliation The Division of Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Patrícia Costa Reis,

Affiliation The Division of Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Li Song,

Affiliation The Division of Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Michelle Petri,

Affiliation Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Kathleen E. Sullivan

* E-mail: sullivak@mail.med.upenn.edu

Affiliation The Division of Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯

The SLE Transcriptome Exhibits Evidence of Chronic Endotoxin Exposure and Has Widespread Dysregulation of Non-Coding and Coding RNAs

Lihua Shi,
Zhe Zhang,
Angela M. Yu,
Wei Wang,
Zhi Wei,
Ehtisham Akhter,
Kelly Maurer,
Patrícia Costa Reis,
Li Song,
Michelle Petri

Published: May 5, 2014
https://doi.org/10.1371/journal.pone.0093846

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Monocytes
Is the Subject Area "Monocytes" applicable to this article?

Thanks for your feedback.
Systemic lupus erythematosus
Is the Subject Area "Systemic lupus erythematosus" applicable to this article?

Thanks for your feedback.
Transcriptome analysis
Is the Subject Area "Transcriptome analysis" applicable to this article?

Thanks for your feedback.
Genetic loci
Is the Subject Area "Genetic loci" applicable to this article?

Thanks for your feedback.
Long non-coding RNA
Is the Subject Area "Long non-coding RNA" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Endotoxins
Is the Subject Area "Endotoxins" applicable to this article?

Thanks for your feedback.
Interferons
Is the Subject Area "Interferons" applicable to this article?

Thanks for your feedback.