Model-Driven Redox Pathway Manipulation for Improved Isobutanol Production in Bacillus subtilis Complemented with Experimental Validation and Metabolic Profiling Analysis

Haishan Qi; Shanshan Li; Sumin Zhao; Di Huang; Menglei Xia; Jianping Wen

doi:10.1371/journal.pone.0093815

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Peer-reviewed

Research Article

Model-Driven Redox Pathway Manipulation for Improved Isobutanol Production in Bacillus subtilis Complemented with Experimental Validation and Metabolic Profiling Analysis

Haishan Qi,

Affiliations Key Laboratory of System Bioengineering, Ministry of Education, Tianjin University, Tianjin, People's Republic of China, Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People's Republic of China
⨯
Shanshan Li,

Affiliations Key Laboratory of System Bioengineering, Ministry of Education, Tianjin University, Tianjin, People's Republic of China, Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People's Republic of China
⨯
Sumin Zhao,

Affiliations Key Laboratory of System Bioengineering, Ministry of Education, Tianjin University, Tianjin, People's Republic of China, Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People's Republic of China
⨯
Di Huang,

Affiliations Key Laboratory of System Bioengineering, Ministry of Education, Tianjin University, Tianjin, People's Republic of China, Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People's Republic of China
⨯
Menglei Xia,

Affiliations Key Laboratory of System Bioengineering, Ministry of Education, Tianjin University, Tianjin, People's Republic of China, Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People's Republic of China
⨯
Jianping Wen

* E-mail: jpwen@tju.edu.cn

Affiliations Key Laboratory of System Bioengineering, Ministry of Education, Tianjin University, Tianjin, People's Republic of China, Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People's Republic of China, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, People's Republic of China
⨯

Model-Driven Redox Pathway Manipulation for Improved Isobutanol Production in Bacillus subtilis Complemented with Experimental Validation and Metabolic Profiling Analysis

Haishan Qi,
Shanshan Li,
Sumin Zhao,
Di Huang,
Menglei Xia,
Jianping Wen

Published: April 4, 2014
https://doi.org/10.1371/journal.pone.0093815

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