Diagnosis of Pancreatic Neoplasms Using a Novel Method of DNA Methylation Analysis of Mucin Expression in Pancreatic Juice

Seiya Yokoyama; Sho Kitamoto; Michiyo Higashi; Yuko Goto; Taro Hara; Dai Ikebe; Taketo Yamaguchi; Yoshifumi Arisaka; Toru Niihara; Hiroto Nishimata; Sadao Tanaka; Kyoichi Takaori; Surinder K. Batra; Suguru Yonezawa

doi:10.1371/journal.pone.0093760

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Open Access

Peer-reviewed

Research Article

Diagnosis of Pancreatic Neoplasms Using a Novel Method of DNA Methylation Analysis of Mucin Expression in Pancreatic Juice

Seiya Yokoyama,

Affiliation Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Kagoshima, Japan
⨯
Sho Kitamoto,

Affiliation Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Kagoshima, Japan
⨯
Michiyo Higashi,

Affiliation Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Kagoshima, Japan
⨯
Yuko Goto,

Affiliation Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Kagoshima, Japan
⨯
Taro Hara,

Affiliation Division of Endoscopy, Chiba Cancer Center, Chiba, Chiba, Japan
⨯
Dai Ikebe,

Affiliation Division of Surgical Pathology, Chiba Cancer Center, Chiba, Chiba, Japan
⨯
Taketo Yamaguchi,

Affiliation Division of Gastroenterology, Chiba Cancer Center, Chiba, Chiba, Japan
⨯
Yoshifumi Arisaka,

Affiliation Department of Gastroenterology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan
⨯
Toru Niihara,

Affiliation Division of Gastroenterology, Nanpuh Hospital, Kagoshima, Kagoshima, Japan
⨯
Hiroto Nishimata,

Affiliation Division of Gastroenterology, Nanpuh Hospital, Kagoshima, Kagoshima, Japan
⨯
Sadao Tanaka,

Affiliation Division of Surgical Pathology, Nanpuh Hospital, Kagoshima, Kagoshima, Japan
⨯
Kyoichi Takaori,

Affiliation Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan
⨯
Surinder K. Batra,

Affiliation Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
⨯
Suguru Yonezawa

* E-mail: syoneza@m2.kufm.kagoshima-u.ac.jp

Affiliation Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Kagoshima, Japan
⨯

Diagnosis of Pancreatic Neoplasms Using a Novel Method of DNA Methylation Analysis of Mucin Expression in Pancreatic Juice

Seiya Yokoyama,
Sho Kitamoto,
Michiyo Higashi,
Yuko Goto,
Taro Hara,
Dai Ikebe,
Taketo Yamaguchi,
Yoshifumi Arisaka,
Toru Niihara,
Hiroto Nishimata

Published: April 8, 2014
https://doi.org/10.1371/journal.pone.0093760

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DNA methylation
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Gastrointestinal tract
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Gastric cancer
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Gastrointestinal tumors
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Mucin
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Gene expression
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