Efficacy and Dose-Dependent Safety of Intra-Arterial Delivery of Mesenchymal Stem Cells in a Rodent Stroke Model

Dileep R. Yavagal; Baowan Lin; Ami P. Raval; Philip S. Garza; Chuanhui Dong; Weizhao Zhao; Erika B. Rangel; Ian McNiece; Tatjana Rundek; Ralph L. Sacco; Miguel Perez-Pinzon; Joshua M. Hare

doi:10.1371/journal.pone.0093735

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Open Access

Peer-reviewed

Research Article

Efficacy and Dose-Dependent Safety of Intra-Arterial Delivery of Mesenchymal Stem Cells in a Rodent Stroke Model

Dileep R. Yavagal ,

* E-mail: dyavagal@med.miami.edu

Affiliations Cerebral Vascular Disease Research Laboratories, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States of America, Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States of America, Interdisciplinary Stem Cell Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯
Baowan Lin,

Affiliation Cerebral Vascular Disease Research Laboratories, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯
Ami P. Raval,

Affiliations Cerebral Vascular Disease Research Laboratories, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States of America, Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯
Philip S. Garza,

Affiliation Cerebral Vascular Disease Research Laboratories, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯
Chuanhui Dong,

Affiliation Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯
Weizhao Zhao,

Affiliation Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯
Erika B. Rangel,

Affiliation Interdisciplinary Stem Cell Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯
Ian McNiece,

Affiliation Interdisciplinary Stem Cell Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯
Tatjana Rundek,

Affiliation Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯
Ralph L. Sacco,

Affiliation Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯
Miguel Perez-Pinzon,

Affiliations Cerebral Vascular Disease Research Laboratories, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States of America, Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯
Joshua M. Hare

Affiliations Interdisciplinary Stem Cell Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States of America, The Department of Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States of America
⨯

Efficacy and Dose-Dependent Safety of Intra-Arterial Delivery of Mesenchymal Stem Cells in a Rodent Stroke Model

Dileep R. Yavagal,
Baowan Lin,
Ami P. Raval,
Philip S. Garza,
Chuanhui Dong,
Weizhao Zhao,
Erika B. Rangel,
Ian McNiece,
Tatjana Rundek,
Ralph L. Sacco

Published: May 7, 2014
https://doi.org/10.1371/journal.pone.0093735

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Blood flow
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Rodents
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