Affinity- and Specificity-Enhancing Mutations Are Frequent in Multispecific Interactions between TIMP2 and MMPs

Open Access

Peer-reviewed

Research Article

Oz Sharabi,

Affiliation Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
⨯
Jason Shirian,

Affiliation Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
⨯
Moran Grossman,

Affiliation Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
⨯
Mario Lebendiker,

Affiliation Wolfson Center for Structural Biology, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
⨯
Irit Sagi,

Affiliation Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
⨯
Julia Shifman

* E-mail: jshifman@cc.huji.ac.il

Affiliation Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
⨯

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Point mutation
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Mutagenesis
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Substitution mutation
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Protein interactions
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Hydrogen bonding
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Enzyme assays
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Zinc
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Enzyme structure
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