Caspase-2 Maintains Bone Homeostasis by Inducing Apoptosis of Oxidatively-Damaged Osteoclasts

Ramaswamy Sharma; Danielle Callaway; Difernando Vanegas; Michelle Bendele; Marisa Lopez-Cruzan; Diane Horn; Teja Guda; Roberto Fajardo; Sherry Abboud-Werner; Brian Herman

doi:10.1371/journal.pone.0093696

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Peer-reviewed

Research Article

Caspase-2 Maintains Bone Homeostasis by Inducing Apoptosis of Oxidatively-Damaged Osteoclasts

Ramaswamy Sharma,

Affiliation Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Danielle Callaway,

Affiliation Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Difernando Vanegas,

Affiliation Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Michelle Bendele,

Affiliation Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Marisa Lopez-Cruzan,

Affiliation Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Diane Horn,

Affiliation Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Teja Guda,

Affiliation Department of Biomedical Engineering, University of Texas at San Antonio, San Antonio, Texas, United States of America
⨯
Roberto Fajardo,

Affiliation Department of Orthopedics, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Sherry Abboud-Werner,

Affiliation Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Brian Herman

* E-mail: herman@umn.edu

Current address: Office of the Vice-President for Research, University of Minnesota, Minneapolis, Minnesota, United States of America

Affiliation Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯

Caspase-2 Maintains Bone Homeostasis by Inducing Apoptosis of Oxidatively-Damaged Osteoclasts

Ramaswamy Sharma,
Danielle Callaway,
Difernando Vanegas,
Michelle Bendele,
Marisa Lopez-Cruzan,
Diane Horn,
Teja Guda,
Roberto Fajardo,
Sherry Abboud-Werner,
Brian Herman

Published: April 1, 2014
https://doi.org/10.1371/journal.pone.0093696

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Osteoclasts
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Apoptosis
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Oxidative stress
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Bone resorption
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Bone fracture
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