Activation of Mu Opioid Receptors Sensitizes Transient Receptor Potential Vanilloid Type 1 (TRPV1) via β-Arrestin-2-Mediated Cross-Talk

Matthew P. Rowan; Sonya M. Bierbower; Michael A. Eskander; Kalina Szteyn; Elaine D. Por; Ruben Gomez; Nicholas Veldhuis; Nigel W. Bunnett; Nathaniel A. Jeske

doi:10.1371/journal.pone.0093688

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Peer-reviewed

Research Article

Activation of Mu Opioid Receptors Sensitizes Transient Receptor Potential Vanilloid Type 1 (TRPV1) via β-Arrestin-2-Mediated Cross-Talk

Matthew P. Rowan,

Affiliation Department of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Sonya M. Bierbower,

Affiliation Department of Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Michael A. Eskander,

Affiliation Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Kalina Szteyn,

Affiliation Department of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Elaine D. Por,

Affiliation Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Ruben Gomez,

Affiliation Department of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Nicholas Veldhuis,

Affiliation Departments of Pharmacology and Medicine, Monash Institute of Pharmacological Sciences, Parkville, Victoria, Australia
⨯
Nigel W. Bunnett,

Affiliation Departments of Pharmacology and Medicine, Monash Institute of Pharmacological Sciences, Parkville, Victoria, Australia
⨯
Nathaniel A. Jeske

* E-mail: jeske@uthscsa.edu

Affiliations Department of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, Department of Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯

Activation of Mu Opioid Receptors Sensitizes Transient Receptor Potential Vanilloid Type 1 (TRPV1) via β-Arrestin-2-Mediated Cross-Talk

Matthew P. Rowan,
Sonya M. Bierbower,
Michael A. Eskander,
Kalina Szteyn,
Elaine D. Por,
Ruben Gomez,
Nicholas Veldhuis,
Nigel W. Bunnett,
Nathaniel A. Jeske

Published: April 2, 2014
https://doi.org/10.1371/journal.pone.0093688

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