Proteolysis of the Human DNA Polymerase Delta Smallest Subunit p12 by μ-Calpain in Calcium-Triggered Apoptotic HeLa Cells

Xiaoting Fan; Qian Zhang; Chao You; Yuanxia Qian; Jing Gao; Peng Liu; Huiqing Chen; Huifang Song; Yan Chen; Keping Chen; Yajing Zhou

doi:10.1371/journal.pone.0093642

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Open Access

Peer-reviewed

Research Article

Proteolysis of the Human DNA Polymerase Delta Smallest Subunit p12 by μ-Calpain in Calcium-Triggered Apoptotic HeLa Cells

Xiaoting Fan ,

Contributed equally to this work with: Xiaoting Fan, Qian Zhang

Affiliation Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China
⨯
Qian Zhang ,

Contributed equally to this work with: Xiaoting Fan, Qian Zhang

Affiliation Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China
⨯
Chao You,

Affiliation Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China
⨯
Yuanxia Qian,

Affiliation School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China
⨯
Jing Gao,

Affiliation School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China
⨯
Peng Liu,

Affiliation Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China
⨯
Huiqing Chen,

Affiliation Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China
⨯
Huifang Song,

Affiliation Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China
⨯
Yan Chen,

Affiliation Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China
⨯
Keping Chen,

Affiliation Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China
⨯
Yajing Zhou

* E-mail: yajingzhou@ujs.edu.cn

Affiliation Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, People's Republic of China
⨯

Proteolysis of the Human DNA Polymerase Delta Smallest Subunit p12 by μ-Calpain in Calcium-Triggered Apoptotic HeLa Cells

Xiaoting Fan,
Qian Zhang,
Chao You,
Yuanxia Qian,
Jing Gao,
Peng Liu,
Huiqing Chen,
Huifang Song,
Yan Chen,
Keping Chen

Published: April 1, 2014
https://doi.org/10.1371/journal.pone.0093642

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Apoptosis
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HeLa cells
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Immunoprecipitation
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Proteolysis
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DNA damage
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Glutathione chromatography
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Immunoblotting
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