Dexmedetomidine Reduces Isoflurane-Induced Neuroapoptosis Partly by Preserving PI3K/Akt Pathway in the Hippocampus of Neonatal Rats

Yujuan Li; Minting Zeng; Weiqiang Chen; Chuiliang Liu; Fei Wang; Xue Han; Zhiyi Zuo; Shuling Peng

doi:10.1371/journal.pone.0093639

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Research Article

Dexmedetomidine Reduces Isoflurane-Induced Neuroapoptosis Partly by Preserving PI3K/Akt Pathway in the Hippocampus of Neonatal Rats

Yujuan Li ,

Contributed equally to this work with: Yujuan Li, Minting Zeng

* E-mail: yujuan_04@hotmail.com (YL); pslmzk@aliyun.com (SP)

Affiliation Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Minting Zeng ,

Contributed equally to this work with: Yujuan Li, Minting Zeng

Current address: Department of Anesthesiology, Guangzhou Women and Children's Medical Centre of Guangzhou Medical University, Guangzhou, Guangdong, China

Affiliation Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Weiqiang Chen,

Affiliations Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China, Department of Anesthesiology, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou, Guangdong, China
⨯
Chuiliang Liu,

Affiliation Department of Anesthesiology, ChanCheng Center Hospital, Foshan, Guangdong, China
⨯
Fei Wang,

Affiliation Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Xue Han,

Affiliation Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯
Zhiyi Zuo,

Affiliations Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China, Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, United States of America
⨯
Shuling Peng

* E-mail: yujuan_04@hotmail.com (YL); pslmzk@aliyun.com (SP)

Affiliation Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
⨯

Dexmedetomidine Reduces Isoflurane-Induced Neuroapoptosis Partly by Preserving PI3K/Akt Pathway in the Hippocampus of Neonatal Rats

Yujuan Li,
Minting Zeng,
Weiqiang Chen,
Chuiliang Liu,
Fei Wang,
Xue Han,
Zhiyi Zuo,
Shuling Peng

Published: April 17, 2014
https://doi.org/10.1371/journal.pone.0093639

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