Amino Acid Starvation Has Opposite Effects on Mitochondrial and Cytosolic Protein Synthesis

Mark A. Johnson; Sara Vidoni; Romina Durigon; Sarah F. Pearce; Joanna Rorbach; Jiuya He; Gloria Brea-Calvo; Michal Minczuk; Aurelio Reyes; Ian J. Holt; Antonella Spinazzola

doi:10.1371/journal.pone.0093597

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Peer-reviewed

Research Article

Amino Acid Starvation Has Opposite Effects on Mitochondrial and Cytosolic Protein Synthesis

Mark A. Johnson ,

Contributed equally to this work with: Mark A. Johnson, Sara Vidoni, Romina Durigon

Affiliation MRC-Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Cambridge, United Kingdom
⨯
Sara Vidoni ,

Contributed equally to this work with: Mark A. Johnson, Sara Vidoni, Romina Durigon

Affiliation MRC-Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Cambridge, United Kingdom
⨯
Romina Durigon ,

Contributed equally to this work with: Mark A. Johnson, Sara Vidoni, Romina Durigon

Affiliation NIMR-National Institute for Medical Research, Mill Hill, London, United Kingdom
⨯
Sarah F. Pearce,

Affiliation MRC-Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Cambridge, United Kingdom
⨯
Joanna Rorbach,

Affiliation MRC-Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Cambridge, United Kingdom
⨯
Jiuya He,

Affiliation MRC-Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Cambridge, United Kingdom
⨯
Gloria Brea-Calvo,

Affiliation MRC-Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Cambridge, United Kingdom
⨯
Michal Minczuk,

Affiliation MRC-Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Cambridge, United Kingdom
⨯
Aurelio Reyes,

Affiliation MRC-Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Cambridge, United Kingdom
⨯
Ian J. Holt,

Affiliation NIMR-National Institute for Medical Research, Mill Hill, London, United Kingdom
⨯
Antonella Spinazzola

* E-mail: aspinaz@nimr.mrc.ac.uk

Affiliation NIMR-National Institute for Medical Research, Mill Hill, London, United Kingdom
⨯

Amino Acid Starvation Has Opposite Effects on Mitochondrial and Cytosolic Protein Synthesis

Mark A. Johnson,
Sara Vidoni,
Romina Durigon,
Sarah F. Pearce,
Joanna Rorbach,
Jiuya He,
Gloria Brea-Calvo,
Michal Minczuk,
Aurelio Reyes,
Ian J. Holt

Published: April 9, 2014
https://doi.org/10.1371/journal.pone.0093597

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Mitochondria
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Protein synthesis
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Mitochondrial DNA
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Glucose
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Amino acid metabolism
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HEK 293 cells
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