Precise Gene Modification Mediated by TALEN and Single-Stranded Oligodeoxynucleotides in Human Cells

Xiaoling Wang; Yingjia Wang; He Huang; Buyuan Chen; Xinji Chen; Jianda Hu; Tammy Chang; Ren-Jang Lin; Jiing-Kuan Yee

doi:10.1371/journal.pone.0093575

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Peer-reviewed

Research Article

Precise Gene Modification Mediated by TALEN and Single-Stranded Oligodeoxynucleotides in Human Cells

Xiaoling Wang,

Affiliation Department of Virology, Beckman Research Institute of City of Hope, Duarte, California, United States of America
⨯
Yingjia Wang,

Affiliations Department of Virology, Beckman Research Institute of City of Hope, Duarte, California, United States of America, Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China
⨯
He Huang,

Affiliation Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Buyuan Chen,

Affiliations Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, California, United States of America, Department of Hematology, Union Hospital of Fujian Medical University, Fuzhou, Fujian, China
⨯
Xinji Chen,

Affiliations Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, California, United States of America, Department of Hematology, Union Hospital of Fujian Medical University, Fuzhou, Fujian, China
⨯
Jianda Hu,

Affiliation Department of Hematology, Union Hospital of Fujian Medical University, Fuzhou, Fujian, China
⨯
Tammy Chang,

Affiliation Department of Virology, Beckman Research Institute of City of Hope, Duarte, California, United States of America
⨯
Ren-Jang Lin,

Affiliation Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, California, United States of America
⨯
Jiing-Kuan Yee

* E-mail: JYee@coh.org

Affiliation Department of Virology, Beckman Research Institute of City of Hope, Duarte, California, United States of America
⨯

Precise Gene Modification Mediated by TALEN and Single-Stranded Oligodeoxynucleotides in Human Cells

Xiaoling Wang,
Yingjia Wang,
He Huang,
Buyuan Chen,
Xinji Chen,
Jianda Hu,
Tammy Chang,
Ren-Jang Lin,
Jiing-Kuan Yee

Published: April 1, 2014
https://doi.org/10.1371/journal.pone.0093575

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Cloning
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TALENs
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Polymerase chain reaction
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Non-homologous end joining
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