Mutations in UBA3 Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Human Leukemic Cells

• G. Wei Xu,

  Affiliation Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

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• Julia I. Toth,

  Affiliation NCI-designated Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America

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• Sara R. da Silva,

  Affiliation Department of Chemistry, University of Toronto Mississauga, Mississauga, Ontario, Canada

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• Stacey-Lynn Paiva,

  Affiliation Department of Chemistry, University of Toronto Mississauga, Mississauga, Ontario, Canada

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• Julie L. Lukkarila,

  Affiliations Department of Chemistry, University of Toronto Mississauga, Mississauga, Ontario, Canada, HalTech Regional Innovation Centre, Sheridan Institute of Technology and Advanced Learning, Oakville, Ontario, Canada

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• Rose Hurren,

  Affiliation Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

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• Neil Maclean,

  Affiliation Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

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• Mahadeo A. Sukhai,

  Affiliation Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

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• Rabindra N. Bhattacharjee,

  Affiliation Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

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• Carolyn A. Goard,

  Affiliation Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

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• Patrick T. Gunning,

  Affiliation Department of Chemistry, University of Toronto Mississauga, Mississauga, Ontario, Canada

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• Sirano Dhe-Paganon,

  Affiliation Division of Nephrology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America

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• Matthew D. Petroski ,

  * E-mail: aaron.schimmer@utoronto.ca (ADS); petroski@sanfordburnham.org (MDP)

  Affiliation NCI-designated Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America

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• Aaron D. Schimmer

  * E-mail: aaron.schimmer@utoronto.ca (ADS); petroski@sanfordburnham.org (MDP)

  Affiliation Ontario Cancer Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

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