Base Excision Repair of Chemotherapeutically-Induced Alkylated DNA Damage Predominantly Causes Contractions of Expanded GAA Repeats Associated with Friedreich's Ataxia

Open Access

Peer-reviewed

Research Article

Yanhao Lai,

Affiliations Department of Environmental Health, Sichuan University West China School of Public Health, Chengdu, Sichuan, P. R. China, Department of Chemistry and Biochemistry, Florida International University, Miami, Florida, United States of America
⨯
Jill M. Beaver,

Affiliation Department of Chemistry and Biochemistry, Florida International University, Miami, Florida, United States of America
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Karla Lorente,

Affiliation Department of Chemistry and Biochemistry, Florida International University, Miami, Florida, United States of America
⨯
Jonathan Melo,

Affiliation Department of Chemistry and Biochemistry, Florida International University, Miami, Florida, United States of America
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Shyama Ramjagsingh,

Affiliation Department of Chemistry and Biochemistry, Florida International University, Miami, Florida, United States of America
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Irina U. Agoulnik,

Affiliation Department of Cellular Biology and Pharmacology, Florida International University, Miami, Florida, United States of America
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Zunzhen Zhang ,

* E-mail: zhangzunzhen@163.com (ZZ); yualiu@fiu.edu (YL)

Affiliation Department of Environmental Health, Sichuan University West China School of Public Health, Chengdu, Sichuan, P. R. China
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Yuan Liu

* E-mail: zhangzunzhen@163.com (ZZ); yualiu@fiu.edu (YL)

Affiliation Department of Chemistry and Biochemistry, Florida International University, Miami, Florida, United States of America
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DNA repair
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DNA damage
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DNA synthesis
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Nucleases
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Lesions
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Polymerase chain reaction
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Chemotherapeutic agents
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DNA replication
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