ATP6V0C Knockdown in Neuroblastoma Cells Alters Autophagy-Lysosome Pathway Function and Metabolism of Proteins that Accumulate in Neurodegenerative Disease

Leandra R. Mangieri; Burton J. Mader; Cailin E. Thomas; Charles A. Taylor; Austin M. Luker; Tonia E. Tse; Carrie Huisingh; John J. Shacka

doi:10.1371/journal.pone.0093257

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Peer-reviewed

Research Article

ATP6V0C Knockdown in Neuroblastoma Cells Alters Autophagy-Lysosome Pathway Function and Metabolism of Proteins that Accumulate in Neurodegenerative Disease

Leandra R. Mangieri ,

Contributed equally to this work with: Leandra R. Mangieri, Burton J. Mader

Affiliation Department Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Burton J. Mader ,

Contributed equally to this work with: Leandra R. Mangieri, Burton J. Mader

Affiliations Department Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Birmingham Veterans Administration Medical Center, Birmingham, Alabama, United States of America
⨯
Cailin E. Thomas,

Affiliation Department Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Charles A. Taylor,

Affiliation Department Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Austin M. Luker,

Affiliation Department Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Tonia E. Tse,

Affiliation Department Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Carrie Huisingh,

Affiliation Department Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
John J. Shacka

* E-mail: shacka@uab.edu

Affiliations Department Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯

ATP6V0C Knockdown in Neuroblastoma Cells Alters Autophagy-Lysosome Pathway Function and Metabolism of Proteins that Accumulate in Neurodegenerative Disease

Leandra R. Mangieri,
Burton J. Mader,
Cailin E. Thomas,
Charles A. Taylor,
Austin M. Luker,
Tonia E. Tse,
Carrie Huisingh,
John J. Shacka

Published: April 2, 2014
https://doi.org/10.1371/journal.pone.0093257

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