Direct T Cell Activation via CD40 Ligand Generates High Avidity CD8⁺ T Cells Capable of Breaking Immunological Tolerance for the Control of Tumors

• Ruey-Shyang Soong,

  Affiliations Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of General Surgery, Chang Gung Memorial Hospital at Keelung, Keelung City, Taiwan, Chang Gung University, College of Medicine, Taoyuan, Taiwan

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• Liwen Song,

  Affiliations Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Pharmacy School of Fudan University, Shanghai, China, Department of Pharmacology and Toxicology, Shanghai Institute of Planned Parenthood Research, Shanghai, China, Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China

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• Janson Trieu,

  Affiliation Johns Hopkins University, Baltimore, Maryland, United States of America

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• Sung Yong Lee,

  Affiliations Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Internal Medicine, Korea University Medical Center, Seoul, South Korea

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• Liangmei He,

  Affiliation Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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• Ya-Chea Tsai,

  Affiliation Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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• T.-C. Wu ,

  * E-mail: chung2@jhmi.edu (C-FH); wutc@jhmi.edu (T-CW)

  Affiliations Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Obstetrics and Gynecology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Molecular Microbiology and Immunology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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• Chien-Fu Hung

  * E-mail: chung2@jhmi.edu (C-FH); wutc@jhmi.edu (T-CW)

  Affiliations Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America, Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America

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