Cross-Talk between Malarial Cysteine Proteases and Falstatin: The BC Loop as a Hot-Spot Target

Srinivasan Sundararaj; Ajay K. Saxena; Ruby Sharma; Kapil Vashisht; Supriya Sharma; Anup Anvikar; Rajnikant Dixit; Philip J. Rosenthal; Kailash C. Pandey

doi:10.1371/journal.pone.0093008

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Open Access

Peer-reviewed

Research Article

Cross-Talk between Malarial Cysteine Proteases and Falstatin: The BC Loop as a Hot-Spot Target

Srinivasan Sundararaj,

Affiliation Host–Parasite Interaction Biology Group, National Institute of Malaria Research, Indian Council of Medical Research, Dwarka, New Delhi, India
⨯
Ajay K. Saxena,

Affiliation Structural Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
⨯
Ruby Sharma,

Affiliation Structural Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
⨯
Kapil Vashisht,

Affiliation Host–Parasite Interaction Biology Group, National Institute of Malaria Research, Indian Council of Medical Research, Dwarka, New Delhi, India
⨯
Supriya Sharma,

Affiliation Host–Parasite Interaction Biology Group, National Institute of Malaria Research, Indian Council of Medical Research, Dwarka, New Delhi, India
⨯
Anup Anvikar,

Affiliation Host–Parasite Interaction Biology Group, National Institute of Malaria Research, Indian Council of Medical Research, Dwarka, New Delhi, India
⨯
Rajnikant Dixit,

Affiliation Host–Parasite Interaction Biology Group, National Institute of Malaria Research, Indian Council of Medical Research, Dwarka, New Delhi, India
⨯
Philip J. Rosenthal,

Affiliation Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
⨯
Kailash C. Pandey

* E-mail: kailashcp@mrcindia.org

Affiliation Host–Parasite Interaction Biology Group, National Institute of Malaria Research, Indian Council of Medical Research, Dwarka, New Delhi, India
⨯

Cross-Talk between Malarial Cysteine Proteases and Falstatin: The BC Loop as a Hot-Spot Target

Srinivasan Sundararaj,
Ajay K. Saxena,
Ruby Sharma,
Kapil Vashisht,
Supriya Sharma,
Anup Anvikar,
Rajnikant Dixit,
Philip J. Rosenthal,
Kailash C. Pandey

Published: April 3, 2014
https://doi.org/10.1371/journal.pone.0093008

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Hemoglobin
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Cysteine proteases
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Hydrolysis
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Plasmodium
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Proteases
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Malaria
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Malarial parasites
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Hydrogen bonding
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