Dichloroacetate Enhances Adriamycin-Induced Hepatoma Cell Toxicity In Vitro and In Vivo by Increasing Reactive Oxygen Species Levels

Yunhai Dai; Xiaopeng Xiong; Gang Huang; Jianjun Liu; Shile Sheng; Hongjian Wang; Wenxin Qin

doi:10.1371/journal.pone.0092962

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Peer-reviewed

Research Article

Dichloroacetate Enhances Adriamycin-Induced Hepatoma Cell Toxicity In Vitro and In Vivo by Increasing Reactive Oxygen Species Levels

Yunhai Dai ,

Contributed equally to this work with: Yunhai Dai, Xiaopeng Xiong

Affiliations Department of Nuclear Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China
⨯
Xiaopeng Xiong ,

Contributed equally to this work with: Yunhai Dai, Xiaopeng Xiong

Affiliations Department of Nuclear Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China
⨯
Gang Huang ,

* E-mail: huanggangmed@163.com

Affiliations Department of Nuclear Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China
⨯
Jianjun Liu,

Affiliations Department of Nuclear Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China
⨯
Shile Sheng,

Affiliations Department of Nuclear Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China
⨯
Hongjian Wang,

Affiliation Department of Gastroenterology, Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
⨯
Wenxin Qin

Affiliation National Laboratory for Oncogenes and Related Genes, WHO Collaborating Center for Research on Cancer, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China
⨯

Dichloroacetate Enhances Adriamycin-Induced Hepatoma Cell Toxicity In Vitro and In Vivo by Increasing Reactive Oxygen Species Levels

Yunhai Dai,
Xiaopeng Xiong,
Gang Huang,
Jianjun Liu,
Shile Sheng,
Hongjian Wang,
Wenxin Qin

Published: April 11, 2014
https://doi.org/10.1371/journal.pone.0092962

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