Involvement of Interleukin-17A-Induced Hypercontractility of Intestinal Smooth Muscle Cells in Persistent Gut Motor Dysfunction

Hirotada Akiho; Yohei Tokita; Kazuhiko Nakamura; Kazuko Satoh; Mitsue Nishiyama; Naoko Tsuchiya; Kazuaki Tsuchiya; Katsuya Ohbuchi; Yoichiro Iwakura; Eikichi Ihara; Ryoichi Takayanagi; Masahiro Yamamoto

doi:10.1371/journal.pone.0092960

Loading metrics

Open Access

Peer-reviewed

Research Article

Involvement of Interleukin-17A-Induced Hypercontractility of Intestinal Smooth Muscle Cells in Persistent Gut Motor Dysfunction

Hirotada Akiho ,

* E-mail: akiho@med.kyushu-u.ac.jp

Affiliations Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Department of Gastroenterology, Kitakyushu Municipal Medical Center, Fukuoka, Japan
⨯
Yohei Tokita,

Affiliation Tsumura Research Laboratories, Tsumura & Co., Ibaraki, Japan
⨯
Kazuhiko Nakamura,

Affiliation Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Kazuko Satoh,

Affiliation Tsumura Research Laboratories, Tsumura & Co., Ibaraki, Japan
⨯
Mitsue Nishiyama,

Affiliation Tsumura Research Laboratories, Tsumura & Co., Ibaraki, Japan
⨯
Naoko Tsuchiya,

Affiliation Tsumura Research Laboratories, Tsumura & Co., Ibaraki, Japan
⨯
Kazuaki Tsuchiya,

Affiliation Tsumura Research Laboratories, Tsumura & Co., Ibaraki, Japan
⨯
Katsuya Ohbuchi,

Affiliation Tsumura Research Laboratories, Tsumura & Co., Ibaraki, Japan
⨯
Yoichiro Iwakura,

Affiliations Division of Laboratory Animal, Research Institute for Biomedical Science, Tokyo University of Science, Chiba, Japan, Core Research for Evolutional Science and Technology (CREST), JST, Saitama, Japan
⨯
Eikichi Ihara,

Affiliation Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Ryoichi Takayanagi,

Affiliation Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Masahiro Yamamoto

Affiliation Tsumura Research Laboratories, Tsumura & Co., Ibaraki, Japan
⨯

Involvement of Interleukin-17A-Induced Hypercontractility of Intestinal Smooth Muscle Cells in Persistent Gut Motor Dysfunction

Hirotada Akiho,
Yohei Tokita,
Kazuhiko Nakamura,
Kazuko Satoh,
Mitsue Nishiyama,
Naoko Tsuchiya,
Kazuaki Tsuchiya,
Katsuya Ohbuchi,
Yoichiro Iwakura,
Eikichi Ihara

Published: May 5, 2014
https://doi.org/10.1371/journal.pone.0092960

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Gastrointestinal tract
Is the Subject Area "Gastrointestinal tract" applicable to this article?

Thanks for your feedback.
Membrane proteins
Is the Subject Area "Membrane proteins" applicable to this article?

Thanks for your feedback.
Muscle contraction
Is the Subject Area "Muscle contraction" applicable to this article?

Thanks for your feedback.
Colon
Is the Subject Area "Colon" applicable to this article?

Thanks for your feedback.
Inflammatory bowel disease
Is the Subject Area "Inflammatory bowel disease" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.