A Novel Functional TagSNP Rs7560488 in the DNMT3A1 Promoter Is Associated with Susceptibility to Gastric Cancer by Modulating Promoter Activity

Huazhang Wu; Kun Zhang; Pihai Gong; Fengchang Qiao; Ling Wang; He Cui; Xinyuan Sui; Jifan Gao; Hong Fan

doi:10.1371/journal.pone.0092911

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Open Access

Peer-reviewed

Research Article

A Novel Functional TagSNP Rs7560488 in the DNMT3A1 Promoter Is Associated with Susceptibility to Gastric Cancer by Modulating Promoter Activity

Huazhang Wu ,

Contributed equally to this work with: Huazhang Wu, Kun Zhang

Affiliation The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Departments of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China
⨯
Kun Zhang ,

Contributed equally to this work with: Huazhang Wu, Kun Zhang

Affiliation The Third Affiliated Hospital of Harbin Medical University (Harbin Medical University Cancer Hospital), Harbin, China
⨯
Pihai Gong,

Affiliation The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Departments of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China
⨯
Fengchang Qiao,

Affiliation The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Departments of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China
⨯
Ling Wang,

Affiliation The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Departments of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China
⨯
He Cui,

Affiliation The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Departments of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China
⨯
Xinyuan Sui,

Affiliation The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Departments of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China
⨯
Jifan Gao,

Affiliation The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Departments of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China
⨯
Hong Fan

* E-mail: fanh@seu.edu.cn

Affiliation The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Departments of Medical Genetics and Developmental Biology, Medical School of Southeast University, Nanjing, China
⨯

A Novel Functional TagSNP Rs7560488 in the DNMT3A1 Promoter Is Associated with Susceptibility to Gastric Cancer by Modulating Promoter Activity

Huazhang Wu,
Kun Zhang,
Pihai Gong,
Fengchang Qiao,
Ling Wang,
He Cui,
Xinyuan Sui,
Jifan Gao,
Hong Fan

Published: March 25, 2014
https://doi.org/10.1371/journal.pone.0092911

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DNA methylation
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Gastric cancer
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Variant genotypes
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Single nucleotide polymorphisms
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