Impact of Combined Clenbuterol and Metoprolol Therapy on Reverse Remodelling during Mechanical Unloading

Manoraj Navaratnarajah; Urszula Siedlecka; Michael Ibrahim; Carin van Doorn; Gopal Soppa; Ajay Gandhi; Adarsh Shah; Punam Kukadia; Magdi H. Yacoub; Cesare M. Terracciano

doi:10.1371/journal.pone.0092909

Loading metrics

Open Access

Peer-reviewed

Research Article

Impact of Combined Clenbuterol and Metoprolol Therapy on Reverse Remodelling during Mechanical Unloading

Manoraj Navaratnarajah ,

* E-mail: manonava@hotmail.com

Affiliation Harefield Heart Science Centre, Imperial College London, National Heart and Lung Institute, Laboratory of Cellular Electrophysiology, Harefield Hospital, Harefield, Middlesex, United Kingdom
⨯
Urszula Siedlecka,

Affiliation Harefield Heart Science Centre, Imperial College London, National Heart and Lung Institute, Laboratory of Cellular Electrophysiology, Harefield Hospital, Harefield, Middlesex, United Kingdom
⨯
Michael Ibrahim,

Affiliation Harefield Heart Science Centre, Imperial College London, National Heart and Lung Institute, Laboratory of Cellular Electrophysiology, Harefield Hospital, Harefield, Middlesex, United Kingdom
⨯
Carin van Doorn,

Affiliation Harefield Heart Science Centre, Imperial College London, National Heart and Lung Institute, Laboratory of Cellular Electrophysiology, Harefield Hospital, Harefield, Middlesex, United Kingdom
⨯
Gopal Soppa,

Affiliation Harefield Heart Science Centre, Imperial College London, National Heart and Lung Institute, Laboratory of Cellular Electrophysiology, Harefield Hospital, Harefield, Middlesex, United Kingdom
⨯
Ajay Gandhi,

Affiliation Harefield Heart Science Centre, Imperial College London, National Heart and Lung Institute, Laboratory of Cellular Electrophysiology, Harefield Hospital, Harefield, Middlesex, United Kingdom
⨯
Adarsh Shah,

Affiliation Harefield Heart Science Centre, Imperial College London, National Heart and Lung Institute, Laboratory of Cellular Electrophysiology, Harefield Hospital, Harefield, Middlesex, United Kingdom
⨯
Punam Kukadia,

Affiliation Harefield Heart Science Centre, Imperial College London, National Heart and Lung Institute, Laboratory of Cellular Electrophysiology, Harefield Hospital, Harefield, Middlesex, United Kingdom
⨯
Magdi H. Yacoub,

Affiliation Harefield Heart Science Centre, Imperial College London, National Heart and Lung Institute, Laboratory of Cellular Electrophysiology, Harefield Hospital, Harefield, Middlesex, United Kingdom
⨯
Cesare M. Terracciano

Affiliation Harefield Heart Science Centre, Imperial College London, National Heart and Lung Institute, Laboratory of Cellular Electrophysiology, Harefield Hospital, Harefield, Middlesex, United Kingdom
⨯

Impact of Combined Clenbuterol and Metoprolol Therapy on Reverse Remodelling during Mechanical Unloading

Manoraj Navaratnarajah,
Urszula Siedlecka,
Michael Ibrahim,
Carin van Doorn,
Gopal Soppa,
Ajay Gandhi,
Adarsh Shah,
Punam Kukadia,
Magdi H. Yacoub,
Cesare M. Terracciano

Published: September 30, 2014
https://doi.org/10.1371/journal.pone.0092909

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Heart
Is the Subject Area "Heart" applicable to this article?

Thanks for your feedback.
Atrophy
Is the Subject Area "Atrophy" applicable to this article?

Thanks for your feedback.
Heart failure
Is the Subject Area "Heart failure" applicable to this article?

Thanks for your feedback.
Cardiomyocytes
Is the Subject Area "Cardiomyocytes" applicable to this article?

Thanks for your feedback.
Beta-adrenergic antagonist therapy
Is the Subject Area "Beta-adrenergic antagonist therapy" applicable to this article?

Thanks for your feedback.
Muscle contraction
Is the Subject Area "Muscle contraction" applicable to this article?

Thanks for your feedback.
Drug therapy
Is the Subject Area "Drug therapy" applicable to this article?

Thanks for your feedback.
Rodents
Is the Subject Area "Rodents" applicable to this article?

Thanks for your feedback.