Inhibition of Calcineurin Abrogates While Inhibition of mTOR Promotes Regulatory T Cell Expansion and Graft-Versus-Host Disease Protection by IL-2 in Allogeneic Bone Marrow Transplantation

Open Access

Peer-reviewed

Research Article

Atsushi Satake,

Affiliations Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, First Department of Internal Medicine, Kansai Medical University, Osaka, Japan
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Amanda M. Schmidt,

Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Shosaku Nomura,

Affiliation First Department of Internal Medicine, Kansai Medical University, Osaka, Japan
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Taku Kambayashi

* E-mail: taku.kambayashi@uphs.upenn.edu

Affiliation Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Regulatory T cells
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T cells
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TCR signaling cascade
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Flow cytometry
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T cell receptors
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Signal inhibition
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