Meloxicam Executes Its Antitumor Effects against Hepatocellular Carcinoma in COX-2- Dependent and -Independent Pathways

Xiaofeng Dong; Rui Li; Peng Xiu; Xuesong Dong; Zongzhen Xu; Bo Zhai; Feng Liu; Hongchi Jiang; Xueying Sun; Jie Li; Haiquan Qiao

doi:10.1371/journal.pone.0092864

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Open Access

Peer-reviewed

Research Article

Meloxicam Executes Its Antitumor Effects against Hepatocellular Carcinoma in COX-2- Dependent and -Independent Pathways

Xiaofeng Dong,

Affiliation Department of General Surgery, Qianfoshan Hospital, Shandong University, Jinan, China
⨯
Rui Li,

Affiliation Department of General Surgery, Liaocheng People's Hospital, Liaocheng, China
⨯
Peng Xiu,

Affiliation Department of General Surgery, Qianfoshan Hospital, Shandong University, Jinan, China
⨯
Xuesong Dong,

Affiliation The Hepatosplenic Surgery Center, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China
⨯
Zongzhen Xu,

Affiliation Department of General Surgery, Qianfoshan Hospital, Shandong University, Jinan, China
⨯
Bo Zhai,

Affiliation The Hepatosplenic Surgery Center, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China
⨯
Feng Liu,

Affiliation Department of General Surgery, Qianfoshan Hospital, Shandong University, Jinan, China
⨯
Hongchi Jiang,

Affiliation The Hepatosplenic Surgery Center, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China
⨯
Xueying Sun,

Affiliations The Hepatosplenic Surgery Center, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China, Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
⨯
Jie Li ,

* E-mail: lijie0503@126.com (JL); qiaohaiquan@hotmail.com (HQ)

Affiliation Department of General Surgery, Qianfoshan Hospital, Shandong University, Jinan, China
⨯
Haiquan Qiao

* E-mail: lijie0503@126.com (JL); qiaohaiquan@hotmail.com (HQ)

Affiliation The Hepatosplenic Surgery Center, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China
⨯

Meloxicam Executes Its Antitumor Effects against Hepatocellular Carcinoma in COX-2- Dependent and -Independent Pathways

Xiaofeng Dong,
Rui Li,
Peng Xiu,
Xuesong Dong,
Zongzhen Xu,
Bo Zhai,
Feng Liu,
Hongchi Jiang,
Xueying Sun,
Jie Li

Published: March 27, 2014
https://doi.org/10.1371/journal.pone.0092864

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Autophagic cell death
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Hepatocellular carcinoma
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COX-2 inhibitors
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