Top-Down Proteomics with Mass Spectrometry Imaging: A Pilot Study towards Discovery of Biomarkers for Neurodevelopmental Disorders

Open Access

Peer-reviewed

Research Article

Hui Ye,

Affiliations State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, PR China, Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, PR China, School of Pharmacy, University of Wisconsin Madison, Madison, Wisconsin, United States of America
⨯
Rakesh Mandal,

Affiliation Department of Neurology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
⨯
Adam Catherman,

Affiliation Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, United States of America
⨯
Paul M. Thomas,

Affiliation Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, United States of America
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Neil L. Kelleher,

Affiliation Proteomics Center of Excellence, Northwestern University, Evanston, Illinois, United States of America
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Chrysanthy Ikonomidou ,

* E-mail: ikonomidou@neurology.wisc.edu (CI); lli@pharmacy.wisc.edu (LL)

Affiliation Department of Neurology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
⨯
Lingjun Li

* E-mail: ikonomidou@neurology.wisc.edu (CI); lli@pharmacy.wisc.edu (LL)

Affiliations School of Pharmacy, University of Wisconsin Madison, Madison, Wisconsin, United States of America, Department of Chemistry, University of Wisconsin Madison, Madison, Wisconsin, United States of America
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Matrix-assisted laser desorption ionization mass spectrometry
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Tandem mass spectrometry
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Biomarkers
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Apoptosis
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Receptor antagonist therapy
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Neuroimaging
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Protein sequencing
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Protein expression
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