The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor

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Peer-reviewed

Research Article

The 2.1 Å Resolution Structure of Cyanopindolol-Bound β₁-Adrenoceptor Identifies an Intramembrane Na⁺ Ion that Stabilises the Ligand-Free Receptor

Jennifer L. Miller-Gallacher ,

Contributed equally to this work with: Jennifer L. Miller-Gallacher, Rony Nehmé

Current address: RSR Limited, Cardiff, United Kingdom

Affiliation Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, Cambridgeshire, United Kingdom
⨯
Rony Nehmé ,

Contributed equally to this work with: Jennifer L. Miller-Gallacher, Rony Nehmé

Affiliation Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, Cambridgeshire, United Kingdom
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Tony Warne,

Affiliation Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, Cambridgeshire, United Kingdom
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Patricia C. Edwards,

Affiliation Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, Cambridgeshire, United Kingdom
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Gebhard F. X. Schertler,

Current address: Laboratory of Biomolecular Research, Paul Scherrer Institut, Villigen, Switzerland; Biology Department, ETH Zürich, Zürich, Switzerland

Affiliation Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, Cambridgeshire, United Kingdom
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Andrew G. W. Leslie,

Affiliation Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, Cambridgeshire, United Kingdom
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Christopher G. Tate

* E-mail: cgt@mrc-lmb.cam.ac.uk

Affiliation Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, Cambridgeshire, United Kingdom
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Crystal structure
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G protein coupled receptors
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Crystallization
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Protein structure
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Isoproterenol
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Hydrogen bonding
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Ligand-gated ion channels
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Lipid structure
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