Fast and Accurate Multivariate Gaussian Modeling of Protein Families: Predicting Residue Contacts and Protein-Interaction Partners

Carlo Baldassi; Marco Zamparo; Christoph Feinauer; Andrea Procaccini; Riccardo Zecchina; Martin Weigt; Andrea Pagnani

doi:10.1371/journal.pone.0092721

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Peer-reviewed

Research Article

Fast and Accurate Multivariate Gaussian Modeling of Protein Families: Predicting Residue Contacts and Protein-Interaction Partners

Carlo Baldassi ,

Contributed equally to this work with: Carlo Baldassi, Marco Zamparo

Affiliations Department of Applied Science and Technology and Center for Computational Sciences, Politecnico di Torino, Torino, Italy, Human Genetics Foundation-Torino, Torino, Italy
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Marco Zamparo ,

Contributed equally to this work with: Carlo Baldassi, Marco Zamparo

Affiliations Department of Applied Science and Technology and Center for Computational Sciences, Politecnico di Torino, Torino, Italy, Human Genetics Foundation-Torino, Torino, Italy
⨯
Christoph Feinauer,

Affiliation Department of Applied Science and Technology and Center for Computational Sciences, Politecnico di Torino, Torino, Italy
⨯
Andrea Procaccini,

Affiliation Human Genetics Foundation-Torino, Torino, Italy
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Riccardo Zecchina,

Affiliations Department of Applied Science and Technology and Center for Computational Sciences, Politecnico di Torino, Torino, Italy, Human Genetics Foundation-Torino, Torino, Italy
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Martin Weigt,

Affiliations Sorbonne Universités, Université Pierre et Marie Curie Paris 06, UMR 7238, Computational and Quantitative Biology, Paris, France, Centre National de la Recherche Scientifique, UMR 7238, Computational and Quantitative Biology, Paris, France
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Andrea Pagnani

* E-mail: andrea.pagnani@polito.it

Affiliations Department of Applied Science and Technology and Center for Computational Sciences, Politecnico di Torino, Torino, Italy, Human Genetics Foundation-Torino, Torino, Italy
⨯

Fast and Accurate Multivariate Gaussian Modeling of Protein Families: Predicting Residue Contacts and Protein-Interaction Partners

Carlo Baldassi,
Marco Zamparo,
Christoph Feinauer,
Andrea Procaccini,
Riccardo Zecchina,
Martin Weigt,
Andrea Pagnani

Published: March 24, 2014
https://doi.org/10.1371/journal.pone.0092721

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Protein domains
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Sequence alignment
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Multiple alignment calculation
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Protein structure prediction
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Covariance
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Protein interactions
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Protein structure
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Protein structure comparison
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